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Tbio
GATB
Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial

Protein Summary
Description
Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263985
  • ENSP00000263985
  • ENSG00000059691

Symbol
  • PET112
  • PET112L
  • PET112
  • HSPC199
  • PET112L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.94
histone modification site profile
0.92
molecular function
0.91
protein domain
0.85
transcription factor
0.71


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.61   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 108.61   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
GATC
Tbio
Family:  Enzyme
Novelty:  0.62484697
p_int:  0.99999998
p_ni:  2e-8
Score:  0.982
Data Source:  BioPlex,STRINGDB
QRSL1
Tbio
Family:  Enzyme
Novelty:  0.0076614
p_int:  0.999999329
p_ni:  6.71e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
GLB1L3
Tdark
Family:  Enzyme
Novelty:  1.00833616
p_int:  0.982146456
p_ni:  0.017847955
p_wrong:  0.000005589
Data Source:  BioPlex
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.975842486
p_ni:  0.024157505
p_wrong:  9e-9
Data Source:  BioPlex
LRP1
Tbio
Novelty:  0.00200788
p_int:  0.969059314
p_ni:  0.030940686
Score:  0.155
Data Source:  BioPlex,STRINGDB
TNFSF8
Tbio
Novelty:  0.01292216
p_int:  0.938850082
p_ni:  0.061149914
p_wrong:  4e-9
Data Source:  BioPlex
LINC01561
Tdark
p_int:  0.92914848
p_ni:  0.070851497
p_wrong:  2.4e-8
Data Source:  BioPlex
ADAM18
Tdark
Family:  Enzyme
Novelty:  0.22622379
p_int:  0.925640603
p_ni:  0.074358651
p_wrong:  7.46e-7
Data Source:  BioPlex
MRPL12
Tbio
Novelty:  0.10646542
p_int:  0.90017908
p_ni:  0.099820912
p_wrong:  8e-9
Data Source:  BioPlex
MGARP
Tbio
Novelty:  0.02883753
p_int:  0.896948074
p_ni:  0.103050358
p_wrong:  0.000001567
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
4
1
6.4
84.6
cognitive function measurement
3
1
3
71
self reported educational attainment
2
2
2
66.1
low density lipoprotein cholesterol measurement
1
1
1
32.1
BMI-adjusted hip circumference
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
6.4
84.6
cognitive function measurement
3
71
self reported educational attainment
2
66.1
low density lipoprotein cholesterol measurement
1
32.1
BMI-adjusted hip circumference
1
13.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamyl-tRNA amidotransferase subunit B
VGNC:48883
461539
Macaque
glutamyl-tRNA amidotransferase subunit B
694983
Mouse
MGI:2442496
229487
Rat
RGD:1307864
361974
Dog
glutamyl-tRNA amidotransferase subunit B
VGNC:41128
475464
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamyl-tRNA amidotransferase subunit B
Macaque
glutamyl-tRNA amidotransferase subunit B
Mouse
Rat
Dog
glutamyl-tRNA amidotransferase subunit B
Publication Statistics
PubMed Score 108.61
PubMed score by year
PubTator Score 5.45
PubTator score by year
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Related Publications
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PMID
Year
Title