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Tbio
GATAD2B
Transcriptional repressor p66-beta

Protein Summary
Description
Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. This gene encodes a zinc finger protein transcriptional repressor. The encoded protein is part of the methyl-CpG-binding protein-1 complex, which represses gene expression by deacetylating methylated nucleosomes. Mutations in this gene are linked to intellectual disability and dysmorphic features associated with cognitive disability. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368655
  • ENSP00000357644
  • ENSG00000143614
  • ENST00000576342
  • ENSP00000458280
  • ENSG00000261992
  • ENST00000634544
  • ENSP00000489184

Symbol
  • KIAA1150
  • p68
  • MRD18
  • P66beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.96
microRNA
0.86
interacting protein
0.8
protein complex
0.74
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.4   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 262   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.4   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 262   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (136)
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999999
p_ni:  1e-9
Score:  0.983
Data Source:  BioPlex,STRINGDB
CHD5
Tbio
Family:  Epigenetic
Novelty:  0.06408395
p_int:  0.999999961
p_ni:  3.9e-8
Score:  0.867
Data Source:  BioPlex,STRINGDB
ZNF219
Tbio
Family:  TF
Novelty:  0.17515242
p_int:  0.999999873
p_ni:  1.27e-7
Score:  0.762
Data Source:  BioPlex,STRINGDB
MBD3L1
Tbio
Novelty:  0.11297566
p_int:  0.999999841
p_ni:  1.59e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999825
p_ni:  1.75e-7
Score:  0.987
Data Source:  BioPlex,STRINGDB
MBD2
Tchem
Family:  TF
Novelty:  0.01209635
p_int:  0.999999325
p_ni:  6.73e-7
p_wrong:  2e-9
Score:  0.997
Data Source:  BioPlex,STRINGDB
MBD3
Tbio
Family:  TF
Novelty:  0.04513502
p_int:  0.999998832
p_ni:  0.000001167
Score:  0.999
Data Source:  BioPlex,STRINGDB
MTA3
Tbio
Family:  TF
Novelty:  0.02667635
p_int:  0.999998606
p_ni:  0.000001394
Score:  0.999
Data Source:  BioPlex,STRINGDB
CHD3
Tbio
Family:  Epigenetic
Novelty:  0.00657278
p_int:  0.999994052
p_ni:  0.000005948
Score:  0.996
Data Source:  BioPlex,STRINGDB
PHF20L1
Tbio
Family:  Epigenetic
Novelty:  0.23101523
p_int:  0.99998864
p_ni:  0.00001136
Score:  0.845
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (21)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Reactome
Epigenetic regulation of gene expression
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression
Epigenetic regulation of gene expression
Gene expression (Transcription)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
2
3
3
86
mathematical ability
4
3
4
85.2
diet measurement
3
3
4
73.8
age at first birth measurement
2
2
2
72.4
body height
1
2
2
72.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
86
mathematical ability
4
85.2
diet measurement
4
73.8
age at first birth measurement
2
72.4
body height
2
72.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GATA zinc finger domain containing 2B
VGNC:10647
739005
Macaque
GATA zinc finger domain containing 2B
715789
Mouse
MGI:2443225
229542
Rat
RGD:1308533
310614
Dog
GATA zinc finger domain containing 2B
VGNC:41127
490453
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GATA zinc finger domain containing 2B
Macaque
GATA zinc finger domain containing 2B
Mouse
Rat
Dog
GATA zinc finger domain containing 2B
Publication Statistics
PubMed Score 19.40
PubMed score by year
PubTator Score 29.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title