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Tbio
GATA3
Trans-acting T-cell-specific transcription factor GATA-3

Protein Summary
Description
Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5'-AGATAG-3'. Required for the T-helper 2 (Th2) differentiation process following immune and inflammatory responses. This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346208
  • ENSP00000341619
  • ENSG00000107485
  • ENST00000379328
  • ENSP00000368632
  • ENST00000645492
  • ENSP00000494926

Symbol
  • HDR
  • HDRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
PubMedID
1
transcription factor binding site profile
0.85
kinase perturbation
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1722.06   (req: < 5)
Gene RIFs: 420   (req: <= 3)
Antibodies: 846   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1722.06   (req: >= 5)
Gene RIFs: 420   (req: > 3)
Antibodies: 846   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 119
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0