Tbio GATA2 Endothelial transcription factor GATA-2

Protein Summary

Description

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• P23769
• D3DNB3
• Q53YE0
• Q96BH0
• Q96BH8
• Q9BUJ6

Gene Name

• GATA2

Ensembl ID

• ENST00000341105
• ENSP00000345681
• ENSG00000179348
• ENST00000430265
• ENSP00000400259
• ENST00000487848
• ENSP00000417074

Symbol

• DCML
• IMD21
• NFE1B
• MONOMAC

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
transcription factor perturbation	0.98
molecular function	0.96
PubMedID	0.96
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.73   (req: < 5)

Gene RIFs: 150   (req: <= 3)

Antibodies: 446   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 676.73   (req: >= 5)

Gene RIFs: 150   (req: > 3)

Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (269)

Explore Interacting Targets

1 – 10 of 269

• See Interactions on String-DB

ZFPM1

Tbio

Family:  TF

Novelty:  0.01061715

p_int:  0.999998747

p_ni:  0.000001025

p_wrong:  2.27e-7

Score:  0.986

Data Source:  BioPlex,STRINGDB

TRAPPC9

Tbio

Novelty:  0.02703008

p_int:  0.999883032

p_ni:  0.000116968

Score:  0.209

Data Source:  BioPlex,STRINGDB

TRAPPC10

Tbio

Novelty:  0.03433058

p_int:  0.999456585

p_ni:  0.000543415

Score:  0.189

Data Source:  BioPlex,STRINGDB

TRAPPC4

Tbio

Novelty:  0.05749912

p_int:  0.946076749

p_ni:  0.053923251

Score:  0.189

Data Source:  BioPlex,STRINGDB

IMPDH1

Tclin

Family:  Enzyme

Novelty:  0.00758575

p_int:  0.850198377

p_ni:  0.149801623

Score:  0.216

Data Source:  BioPlex,STRINGDB

LMO2

Tbio

Novelty:  0.0038279

Score:  0.99

Data Source:  STRINGDB

TAL1

Tbio

Family:  TF

Novelty:  0.00294416

Score:  0.99

Data Source:  STRINGDB

LDB1

Tbio

Novelty:  0.01110112

Score:  0.974

Data Source:  STRINGDB

RUNX1

Tbio

Family:  TF

Novelty:  0.0085181

Score:  0.968

Data Source:  STRINGDB

JUN

Tchem

Family:  TF

Novelty:  0.00006856

Score:  0.967

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (21)

Reactome (9)

PathwayCommons (6)

WikiPathways (6)

Developmental Biology (R-HSA-1266738)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160
Reactome	Generic Transcription Pathway	1195 targets	R-HSA-212436
Reactome	Hemostasis	666 targets	R-HSA-109582

Name	Explore in Pharos	Explore in Source
Developmental Biology	1055 targets	R-HSA-1266738
Factors involved in megakaryocyte development and platelet production	139 targets	R-HSA-983231
Gene expression (Transcription)	1452 targets	R-HSA-74160
Generic Transcription Pathway	1195 targets	R-HSA-212436
Hemostasis	666 targets	R-HSA-109582

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (61)

Functions (10)

Components (4)

Processes (47)

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GO Term	Evidence	Assigned by
chromatin binding	Inferred from Direct Assay (IDA)	MGI
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	BHF-UCL
enhancer sequence-specific DNA binding	Inferred from Direct Assay (IDA)	MGI
C2H2 zinc finger domain binding	Inferred from Physical Interaction (IPI)	BHF-UCL
transcription factor binding	Inferred from Physical Interaction (IPI)	BHF-UCL
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Electronic Annotation (IEA)	Ensembl
RNA polymerase II distal enhancer sequence-specific DNA binding	Inferred from Electronic Annotation (IEA)	Ensembl
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations (null)

No disease associations found

GWAS Traits (23)

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1 – 5 of 23

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	2	6	6		98.9
eosinophil count	EFO_0004842	4	4	3	9.4	97
neutrophil count	EFO_0004833	2	3	3		95.6
lymphocyte percentage of leukocytes	EFO_0007993	2	4	4		90.9
monocyte count	EFO_0005091	3	2	3		87.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
monocyte percentage of leukocytes	EFO_0007989	6		98.9
eosinophil count	EFO_0004842	3	9.4	97
neutrophil count	EFO_0004833	3		95.6
lymphocyte percentage of leukocytes	EFO_0007993	4		90.9
monocyte count	EFO_0005091	3		87.4

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UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Alternative splicing
Complete proteome
Disease mutation
DNA-binding
Isopeptide bond
Metal-binding
Methylation
Nucleus
Phagocytosis

GWAS Trait Find Similar Targets

No Header	No Header
basophil count
basophil percentage of leukocytes
body mass index
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
granulocyte count
granulocyte percentage of myeloid white cells
leukocyte count
lymphocyte count

MGI Phenotype Find Similar Targets

No Header	No Header
cardiovascular system phenotype
cellular phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hearing/vestibular/ear phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GATA binding protein 2	VGNC:1824	460672
Macaque	GATA binding protein 2		705551
Mouse	GATA binding protein 2	MGI:95662	14461
Rat	GATA binding protein 2	RGD:2664	25159
Dog	GATA binding protein 2	VGNC:41122	484626

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GATA binding protein 2
Macaque	GATA binding protein 2
Mouse	GATA binding protein 2
Rat	GATA binding protein 2
Dog	GATA binding protein 2

Publication Statistics

PubMed Score 676.73

PubMed score by year

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PubTator Score 397.61

PubTator score by year

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Related Publications

Text Mined References (199)

GeneRif Annotations (150)

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PMID	Year	Title