GATA2
Endothelial transcription factor GATA-2
Protein Summary
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
- ENST00000341105
- ENSP00000345681
- ENSG00000179348
- ENST00000430265
- ENSP00000400259
- ENST00000487848
- ENSP00000417074
- DCML
- IMD21
- NFE1B
- MONOMAC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
transcription factor perturbation | 0.98 | ||
molecular function | 0.96 | ||
PubMedID | 0.96 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 747.98 (req: < 5)
Gene RIFs: 229 (req: <= 3)
Antibodies: 446 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 747.98 (req: >= 5)
Gene RIFs: 229 (req: > 3)
Antibodies: 446 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 57
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0