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Tbio
GATA1
Erythroid transcription factor

Protein Summary
Description
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Activates the transcription of genes involved in erythroid differentiation of K562 erythroleukemia cells, including HBB, HBG1/2, ALAS2 and HMBS (PubMed:24245781). This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376670
  • ENSP00000365858
  • ENSG00000102145

Symbol
  • ERYF1
  • GF1
  • GF1
  • GF-1
  • NFE1
  • XLTT
  • ERYF1
  • NF-E1
  • XLANP
  • XLTDA
  • GATA-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
disease perturbation
0.87
gene perturbation
0.83
phenotype
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.66   (req: < 5)
Gene RIFs: 198   (req: <= 3)
Antibodies: 904   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1286.66   (req: >= 5)
Gene RIFs: 198   (req: > 3)
Antibodies: 904   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (323)
TRIP6
Tbio
Novelty:  0.02183202
p_int:  0.93757784
p_ni:  0.062422155
p_wrong:  5e-9
Score:  0.35
Data Source:  BioPlex,STRINGDB
LMO2
Tbio
Novelty:  0.0038279
Score:  0.999
Data Source:  STRINGDB
ZFPM1
Tbio
Family:  TF
Novelty:  0.01061715
Score:  0.995
Data Source:  Reactome,STRINGDB
TAL1
Tbio
Family:  TF
Novelty:  0.00294416
Score:  0.994
Data Source:  STRINGDB
LDB1
Tbio
Novelty:  0.01110112
Score:  0.988
Data Source:  STRINGDB
MYB
Tbio
Family:  TF
Novelty:  0.00092053
Score:  0.985
Data Source:  STRINGDB
AHSP
Tbio
Novelty:  0.00996928
Score:  0.975
Data Source:  STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.972
Data Source:  STRINGDB
EP300
Tchem
Family:  Epigenetic
Novelty:  0.00055009
Score:  0.972
Data Source:  STRINGDB
ZFPM2
Tbio
Family:  TF
Novelty:  0.01019523
Score:  0.968
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hemostasis
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Generic Transcription Pathway
Hemostasis
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (55)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
BHF-UCL
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
1
2
2
90
eosinophil percentage of leukocytes
1
1
1
82.8
platelet count
1
1
1
57.8
mean platelet volume
1
1
1
15.5
1
1
0
1.1
2.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
90
eosinophil percentage of leukocytes
1
82.8
platelet count
1
57.8
mean platelet volume
1
15.5
0
1.1
2.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
GATA binding protein 1
714631
Mouse
MGI:95661
14460
Rat
RGD:2663
25172
Cow
GATA binding protein 1
VGNC:29265
516066
Pig
GATA binding protein 1
100620659
Species
Name
OMA
EggNOG
Inparanoid
Macaque
GATA binding protein 1
Mouse
Rat
Cow
GATA binding protein 1
Pig
GATA binding protein 1
Publication Statistics
PubMed Score 1286.66
PubMed score by year
PubTator Score 782.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title