Protein Summary
Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine. Gastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic factor for gastrointestinal epithelial cells. Gastrin has two biologically active peptide forms, G34 and G17. [provided by RefSeq, Jul 2008]
- ENST00000329402
- ENSP00000331358
- ENSG00000184502
- GAS
- GAS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease | 0.95 | ||
gene perturbation | 0.81 | ||
chemical | 0.77 | ||
biological term | 0.51 | ||
cell line | 0.47 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8648.08 (req: < 5)
Gene RIFs: 77 (req: <= 3)
Antibodies: 395 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8648.08 (req: >= 5)
Gene RIFs: 77 (req: > 3)
Antibodies: 395 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (287)
GTSE1
Family: Enzyme
Novelty: 0.0460569
p_int: 0.999999573
p_ni: 3.7e-8
p_wrong: 3.9e-7
Score: 0.67
Data Source: BioPlex,STRINGDB
BCAR3
Novelty: 0.05420404
p_int: 0.999999408
p_ni: 5.86e-7
p_wrong: 6e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
PCDHB16
Novelty: 0.67206411
p_int: 0.99997316
p_ni: 0.000026764
p_wrong: 7.6e-8
Data Source: BioPlex
XAGE3
Novelty: 0.1418603
p_int: 0.999961321
p_ni: 0.000038679
Score: 0.558
Data Source: BioPlex,STRINGDB
ATE1
Family: Enzyme
Novelty: 0.01672896
p_int: 0.997887773
p_ni: 0.002112227
Score: 0.181
Data Source: BioPlex,STRINGDB
HECTD3
Family: Enzyme
Novelty: 2.20874654
p_int: 0.772394275
p_ni: 0.227605725
Data Source: BioPlex
Nearest Tclin Targets (1)
Downstream (1)
1 – 1 of 1
Pathways (159)
Reactome (5)
KEGG (1)
PathwayCommons (7)
WikiPathways (146)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Reactome | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by GPCR | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
Gastrin-CREB signalling pathway via PKC and MAPK | ||||
Signal Transduction | ||||
Signaling by GPCR | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (1)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 2 | 4 | 78.7 | |||||
balding measurement | 1 | 1 | 1 | 64.4 | |||||
1 | 1 | 0 | 1.3 | 17.7 | |||||
1 | 1 | 0 | 1.3 | 17.7 | |||||
viral load | 1 | 1 | 1 | 15.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 78.7 | |||||
balding measurement | 1 | 64.4 | |||||
0 | 1.3 | 17.7 | |||||
0 | 1.3 | 17.7 | |||||
viral load | 1 | 15.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | gastrin | VGNC:12143 | 468262 | |||||
Mouse | MGI:104768 | 14459 | ||||||
Rat | RGD:2662 | 25320 | ||||||
Dog | gastrin | VGNC:41121 | 100685087 | |||||
Horse | gastrin | VGNC:49456 | 100034214 | |||||
Publication Statistics
PubMed Score 8648.08
PubMed score by year
PubTator Score 5778.62
PubTator score by year
Related Publications
Text Mined References (114)
GeneRif Annotations (77)
Items per page:
0 of 0
PMID | Year | Title |
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