Tbio GAS1 Growth arrest-specific protein 1

Protein Summary

Description

Specific growth arrest protein involved in growth suppression. Blocks entry to S phase. Prevents cycling of normal and transformed cells. Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P54826
• B9EGM4
• Q6B086
• GAS-1

Gene Name

• GAS1

Ensembl ID

• ENST00000298743
• ENSP00000298743
• ENSG00000180447

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.94
gene perturbation	0.87
transcription factor perturbation	0.84
biological process	0.83
histone modification site profile	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.82   (req: < 5)

Gene RIFs: 27   (req: <= 3)

Antibodies: 215   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 297.82   (req: >= 5)

Gene RIFs: 27   (req: > 3)

Antibodies: 215   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0