GAREM1
GRB2-associated and regulator of MAPK protein 1
Protein Summary
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000269209
- ENSP00000269209
- ENSG00000141441
- ENST00000399218
- ENSP00000382165
- C18orf11
- FAM59A
- GAREM
- GAREM
- Gm944
- FAM59A
- C18orf11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.39 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 104 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5.39 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 104 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (28)
GRB2
Novelty: 0.00091605
p_int: 0.999999959
p_ni: 3.8e-8
p_wrong: 3e-9
Score: 0.692
Data Source: BioPlex,STRINGDB
GRAP2
Novelty: 0.00503901
p_int: 0.999999529
p_ni: 4.71e-7
Score: 0.453
Data Source: BioPlex,STRINGDB
SHC4
Novelty: 0.04623367
p_int: 0.999982821
p_ni: 0.000017178
p_wrong: 1e-9
Score: 0.313
Data Source: BioPlex,STRINGDB
EFNA1
Family: Kinase
Novelty: 0.00732252
p_int: 0.998250886
p_ni: 0.001711005
p_wrong: 0.000038109
Score: 0.691
Data Source: BioPlex,STRINGDB
SHC1
Novelty: 0.00083615
p_int: 0.994562612
p_ni: 0.005400901
p_wrong: 0.000036487
Score: 0.357
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
PathwayCommons (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: netpath | EGFR1 | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
EGFR1 | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (1)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
TNF-related apoptosis-inducing ligand measurement | 1 | 1 | 1 | 58.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 1 | 1 | 24.5 | |||||
left ventricular systolic function measurement | 1 | 1 | 1 | 0.2 | |||||
left ventricular diastolic function measurement | 1 | 1 | 1 | 0.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
TNF-related apoptosis-inducing ligand measurement | 1 | 58.4 | |||||
high density lipoprotein cholesterol measurement | 1 | 24.5 | |||||
left ventricular systolic function measurement | 1 | 0.2 | |||||
left ventricular diastolic function measurement | 1 | 0.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | GRB2 associated regulator of MAPK1 subtype 1 | VGNC:13262 | 468614 | |||||
Mouse | MGI:2685790 | 381126 | ||||||
Dog | GRB2 associated regulator of MAPK1 subtype 1 | VGNC:53484 | 490496 | |||||
Horse | GRB2 associated regulator of MAPK1 subtype 1 | VGNC:18246 | 100066443 | |||||
Cow | GRB2 associated regulator of MAPK1 subtype 1 | VGNC:29252 | 507330 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | GRB2 associated regulator of MAPK1 subtype 1 | |||||
Mouse | ||||||
Dog | GRB2 associated regulator of MAPK1 subtype 1 | |||||
Horse | GRB2 associated regulator of MAPK1 subtype 1 | |||||
Cow | GRB2 associated regulator of MAPK1 subtype 1 | |||||
Publication Statistics
PubMed Score 5.39
PubMed score by year
PubTator Score 3.81
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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