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Tbio
GAREM1
GRB2-associated and regulator of MAPK protein 1

Protein Summary
Description
Isoform 1: Acts as an adapter protein that plays a role in intracellular signaling cascades triggered either by the cell surface activated epidermal growth factor receptor and/or cytoplasmic protein tyrosine kinases. Promotes activation of the MAPK/ERK signaling pathway. Plays a role in the regulation of cell proliferation. This gene encodes an adaptor protein which functions in the epidermal growth factor (EGF) receptor-mediated signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269209
  • ENSP00000269209
  • ENSG00000141441
  • ENST00000399218
  • ENSP00000382165

Symbol
  • C18orf11
  • FAM59A
  • GAREM
  • GAREM
  • Gm944
  • FAM59A
  • C18orf11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.39   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999999959
p_ni:  3.8e-8
p_wrong:  3e-9
Score:  0.692
Data Source:  BioPlex,STRINGDB
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.999999529
p_ni:  4.71e-7
Score:  0.453
Data Source:  BioPlex,STRINGDB
SHC4
Tbio
Novelty:  0.04623367
p_int:  0.999982821
p_ni:  0.000017178
p_wrong:  1e-9
Score:  0.313
Data Source:  BioPlex,STRINGDB
EFNA1
Tbio
Family:  Kinase
Novelty:  0.00732252
p_int:  0.998250886
p_ni:  0.001711005
p_wrong:  0.000038109
Score:  0.691
Data Source:  BioPlex,STRINGDB
SHC1
Tchem
Novelty:  0.00083615
p_int:  0.994562612
p_ni:  0.005400901
p_wrong:  0.000036487
Score:  0.357
Data Source:  BioPlex,STRINGDB
THEMIS2
Tbio
Novelty:  0.05609377
Score:  0.731
Data Source:  STRINGDB
SAXO1
Tbio
Novelty:  0.44152272
Score:  0.587
Data Source:  STRINGDB
MAPRE2
Tbio
Novelty:  0.00692773
Score:  0.585
Data Source:  STRINGDB
CCDC178
Tdark
Novelty:  0.59356582
Score:  0.581
Data Source:  STRINGDB
C18orf21
Tdark
Novelty:  0.65363998
Score:  0.548
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TNF-related apoptosis-inducing ligand measurement
1
1
1
58.4
high density lipoprotein cholesterol measurement
1
1
1
24.5
left ventricular systolic function measurement
1
1
1
0.2
left ventricular diastolic function measurement
1
1
1
0.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
TNF-related apoptosis-inducing ligand measurement
1
58.4
high density lipoprotein cholesterol measurement
1
24.5
left ventricular systolic function measurement
1
0.2
left ventricular diastolic function measurement
1
0.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated regulator of MAPK1 subtype 1
VGNC:13262
468614
Mouse
MGI:2685790
381126
Dog
GRB2 associated regulator of MAPK1 subtype 1
VGNC:53484
490496
Horse
GRB2 associated regulator of MAPK1 subtype 1
VGNC:18246
100066443
Cow
GRB2 associated regulator of MAPK1 subtype 1
VGNC:29252
507330
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated regulator of MAPK1 subtype 1
Mouse
Dog
GRB2 associated regulator of MAPK1 subtype 1
Horse
GRB2 associated regulator of MAPK1 subtype 1
Cow
GRB2 associated regulator of MAPK1 subtype 1
Publication Statistics
PubMed Score 5.39
PubMed score by year
PubTator Score 3.81
PubTator score by year
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Related Publications
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PMID
Year
Title