Tbio GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1

Protein Summary

Description

Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras.

Uniprot Accession IDs

• Q14C86
• A8MYK3
• B0QZ62
• B0QZ63
• B0QZ64
• Q14C76
• Q2Q1W1
• Q8ND92
• Q8WU86
• Q96CZ4
• Q9NXQ1
• Q9P207
• Q9Y4N0

Gene Name

• GAPVD1

Ensembl ID

• ENST00000297933
• ENSP00000297933
• ENSG00000165219
• ENST00000312123
• ENSP00000309582
• ENST00000394104
• ENSP00000377664
• ENST00000394105
• ENSP00000377665
• ENST00000470056
• ENSP00000419767
• ENST00000495955
• ENSP00000419063

Symbol

• GAPEX5
• KIAA1521
• RAP6
• RAP6
• GAPEX5
• GAPex-5

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
kinase perturbation	0.96
disease perturbation	0.95
protein complex	0.87
histone modification site profile	0.86

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Gtpase-activating Protein And Vps9 Domain-containing Protein 1

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Gtpase-activating Protein And Vps9 Domain-containing Protein 1

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Guanyl-nucleotide Exchange Factor / Gtpase-activating Protein And Vps9 Domain-containing Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.26   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 88   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.26   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0