Tbio GAPDHS Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

Protein Summary

Description

May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity). This gene encodes a protein belonging to the glyceraldehyde-3-phosphate dehydrogenase family of enzymes that play an important role in carbohydrate metabolism. Like its somatic cell counterpart, this sperm-specific enzyme functions in a nicotinamide adenine dinucleotide-dependent manner to remove hydrogen and add phosphate to glyceraldehyde 3-phosphate to form 1,3-diphosphoglycerate. During spermiogenesis, this enzyme may play an important role in regulating the switch between different energy-producing pathways, and it is required for sperm motility and male fertility. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O14556
• B2RC82
• O60823
• Q6JTT9
• Q9HCU6

Gene Name

• GAPDHS

Ensembl ID

• ENST00000222286
• ENSP00000222286
• ENSG00000105679

Symbol

• GAPD2
• GAPDH2
• GAPDS
• GAPD2
• GAPDS
• HSD-35
• GAPDH-2
• HEL-S-278

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
gene perturbation	0.74
molecular function	0.6
cellular component	0.58
cell type or tissue	0.55

Protein Classes

PANTHER Classes

Protein / Oxidoreductase / Dehydrogenase / Glyceraldehyde-3-phosphate Dehydrogenase, Testis-specific

DTO Classes

Protein / Enzyme / Oxidoreductase / Dehydrogenase / Glyceraldehyde-3-phosphate Dehydrogenase, Testis-specific

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.12   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 205   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 128.12   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0