You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GAPDH
Glyceraldehyde-3-phosphate dehydrogenase

Protein Summary
Description
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules (By similarity). Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibitio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229239
  • ENSP00000229239
  • ENSG00000111640
  • ENST00000396858
  • ENSP00000380067
  • ENST00000396859
  • ENSP00000380068
  • ENST00000396861
  • ENSP00000380070
  • ENST00000619601
  • ENSP00000478864

Symbol
  • GAPD
  • G3PD
  • GAPD
  • HEL-S-162eP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
chemical
0.96
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14926.63   (req: < 5)
Gene RIFs: 131   (req: <= 3)
Antibodies: 2468   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14926.63   (req: >= 5)
Gene RIFs: 131   (req: > 3)
Antibodies: 2468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 5
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0