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Tbio
GAP43
Neuromodulin

Protein Summary
Description
This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000305124
  • ENSP00000305010
  • ENSG00000172020
  • ENST00000393780
  • ENSP00000377372

Symbol
  • B-50
  • PP46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
hub protein
0.79
PubMedID
0.79
protein domain
0.73
chemical
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 997.34   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 785   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 997.34   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 785   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.992767301
p_ni:  0.007232699
Data Source:  BioPlex
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.984971673
p_ni:  0.015028241
p_wrong:  8.6e-8
Data Source:  BioPlex
DCUN1D2
Tchem
Novelty:  1.02957984
p_int:  0.969928449
p_ni:  0.020405854
p_wrong:  0.009665697
Data Source:  BioPlex
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
p_int:  0.936982189
p_ni:  0.063017811
Score:  0.196
Data Source:  BioPlex,STRINGDB
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.935494715
p_ni:  0.064505283
p_wrong:  2e-9
Data Source:  BioPlex
PCDHGC3
Tbio
Novelty:  0.07203024
p_int:  0.93240237
p_ni:  0.067597557
p_wrong:  7.3e-8
Score:  0.185
Data Source:  BioPlex,STRINGDB
KIFAP3
Tbio
Novelty:  0.01902437
p_int:  0.908176751
p_ni:  0.091823249
Score:  0.165
Data Source:  BioPlex,STRINGDB
GJB7
Tbio
Novelty:  0.12555147
p_int:  0.896693965
p_ni:  0.103306035
Data Source:  BioPlex
TIGD5
Tdark
Novelty:  1.93340494
p_int:  0.89084985
p_ni:  0.109150148
p_wrong:  2e-9
Data Source:  BioPlex
BIRC2
Tchem
Novelty:  0.00199701
p_int:  0.882318698
p_ni:  0.117678776
p_wrong:  0.000002526
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
L1CAM interactions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
3.6
mathematical ability
1
1
1
2.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
3.6
mathematical ability
1
2.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth associated protein 43
VGNC:11399
460599
Macaque
growth associated protein 43
711260
Mouse
MGI:95639
14432
Rat
RGD:62071
29423
Dog
growth associated protein 43
VGNC:41108
478572
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth associated protein 43
Macaque
growth associated protein 43
Mouse
Rat
Dog
growth associated protein 43
Publication Statistics
PubMed Score 997.34
PubMed score by year
PubTator Score 645.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title