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Tchem
GANC
Neutral alpha-glucosidase C

Protein Summary
Description
Has alpha-glucosidase activity. Glycosyl hydrolase enzymes hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. This gene encodes a member of glycosyl hydrolases family 31. This enzyme hydrolyses terminal, non-reducing 1,4-linked alpha-D-glucose residues and releases alpha-D-glucose. This is a key enzyme in glycogen metabolism and its gene localizes to a chromosomal region (15q15) that is associated with susceptibility to diabetes. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318010
  • ENSP00000326227
  • ENSG00000214013
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.69
transcription factor
0.59
protein domain
0.58
tissue sample
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.62   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 104   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.62   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 104   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (47)
GLA
Tclin
Family:  Enzyme
Novelty:  0.00075604
Score:  0.971
Data Source:  STRINGDB
SI
Tchem
Family:  Enzyme
Novelty:  0.00048694
Score:  0.924
Data Source:  STRINGDB
MGAM2
Tdark
Family:  Enzyme
Novelty:  0.03471933
Score:  0.921
Data Source:  STRINGDB
AMY1A
Tchem
Family:  Enzyme
Novelty:  0.00210045
Score:  0.92
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.918
Data Source:  STRINGDB
AMY2B
Tbio
Family:  Enzyme
Novelty:  0.01126737
Score:  0.918
Data Source:  STRINGDB
AMY2A
Tclin
Family:  Enzyme
Novelty:  0.00132709
Score:  0.909
Data Source:  STRINGDB
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
Score:  0.906
Data Source:  STRINGDB
PRKCSH
Tbio
Family:  Enzyme
Novelty:  0.00787916
Score:  0.879
Data Source:  STRINGDB
GNPTG
Tbio
Family:  Enzyme
Novelty:  0.03345886
Score:  0.821
Data Source:  STRINGDB
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Starch and sucrose metabolism
KEGG
Metabolic pathways
KEGG
Galactose metabolism
Name
Explore in Pharos
Explore in Source
Starch and sucrose metabolism
Metabolic pathways
Galactose metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
4
9
7
94.2
monocyte percentage of leukocytes
2
1
2
82.1
IGF-1 measurement
1
1
1
78.4
serum albumin measurement
1
1
1
76.7
high density lipoprotein cholesterol measurement
2
2
2
69.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
7
94.2
monocyte percentage of leukocytes
2
82.1
IGF-1 measurement
1
78.4
serum albumin measurement
1
76.7
high density lipoprotein cholesterol measurement
2
69.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosidase alpha, neutral C
VGNC:14640
Macaque
glucosidase alpha, neutral C
708126
Mouse
MGI:1923301
76051
Rat
RGD:2660
24382
Dog
glucosidase alpha, neutral C
VGNC:41107
487517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosidase alpha, neutral C
Macaque
glucosidase alpha, neutral C
Mouse
Rat
Dog
glucosidase alpha, neutral C
Publication Statistics
PubMed Score 40.62
PubMed score by year
PubTator Score 7.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title