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Tchem
GANAB
Neutral alpha-glucosidase AB

Protein Summary
Description
Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins (PubMed:10929008). Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia (PubMed:27259053). This gene encodes the alpha subunit of glucosidase II and a member of the glycosyl hydrolase 31 family of proteins. The heterodimeric enzyme glucosidase II plays a role in protein folding and quality control by cleaving glucose residues from immature glycoproteins in the endoplasmic reticulum. Expression of the encoded protein is elevated in lung tumor tissue and in response to UV irradiation. Mutations in this gene cause autosomal-dominant polycystic kidney and liver disease. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346178
  • ENSP00000340466
  • ENSG00000089597
  • ENST00000356638
  • ENSP00000349053
  • ENST00000526210
  • ENSP00000433799
  • ENST00000532402
  • ENSP00000432181
  • ENST00000534613
  • ENSP00000434921

Symbol
  • G2AN
  • KIAA0088
  • G2AN
  • GIIA
  • PKD3
  • GLUII
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
disease perturbation
0.99
cellular component
0.73
tissue sample
0.69
transcription factor binding site profile
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.01   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 79.01   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (73)
UBAC1
Tbio
Novelty:  0.00122518
p_int:  0.949077858
p_ni:  0.050922142
Data Source:  BioPlex
TAB1
Tchem
Family:  Kinase
Novelty:  0.00721424
p_int:  0.947392338
p_ni:  0.052389947
p_wrong:  0.000217715
Score:  0.326
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.946665422
p_ni:  0.053334578
Score:  0.287
Data Source:  BioPlex,STRINGDB
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.92965123
p_ni:  0.07034877
Score:  0.257
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.905227616
p_ni:  0.094772384
Score:  0.578
Data Source:  BioPlex,STRINGDB
ZNF703
Tbio
Novelty:  0.03956045
p_int:  0.86432693
p_ni:  0.135673053
p_wrong:  1.7e-8
Score:  0.309
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.83507758
p_ni:  0.16492242
Score:  0.256
Data Source:  BioPlex,STRINGDB
RUFY3
Tbio
Novelty:  0.1517817
p_int:  0.824991941
p_ni:  0.175008059
Score:  0.19
Data Source:  BioPlex,STRINGDB
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.796164021
p_ni:  0.203835979
Score:  0.225
Data Source:  BioPlex,STRINGDB
CCT6A
Tbio
Novelty:  0.02368046
p_int:  0.759103382
p_ni:  0.240896618
Score:  0.185
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
4
10
11
95.9
waist-hip ratio
2
6
7
95.1
waist circumference
1
4
4
92.1
BMI-adjusted waist circumference
1
4
4
90.4
forced expiratory volume
2
2
2
89.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
11
95.9
waist-hip ratio
7
95.1
waist circumference
4
92.1
BMI-adjusted waist circumference
4
90.4
forced expiratory volume
2
89.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucosidase II alpha subunit
VGNC:10182
451258
Macaque
glucosidase II alpha subunit
718672
Mouse
MGI:1097667
14376
Rat
RGD:1309775
293721
Dog
glucosidase II alpha subunit
VGNC:41106
483784
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucosidase II alpha subunit
Macaque
glucosidase II alpha subunit
Mouse
Rat
Dog
glucosidase II alpha subunit
Publication Statistics
PubMed Score 79.01
PubMed score by year
PubTator Score 29.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title