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Tbio
GAN
Gigaxonin

Protein Summary
Description
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. May act as a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB. Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival. This gene encodes a member of the cytoskeletal BTB/kelch (Broad-Complex, Tramtrack and Bric a brac) repeat family. The encoded protein plays a role in neurofilament architecture and is involved in mediating the ubiquitination and degradation of some proteins. Defects in this gene are a cause of giant axonal neuropathy (GAN). [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000568107
  • ENSP00000476795
  • ENSG00000261609
  • ENST00000648994
  • ENSP00000497351

Symbol
  • GAN1
  • KLHL16
  • GAN1
  • KLHL16
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.87
transcription factor binding site profile
0.86
microRNA
0.82
tissue
0.7


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.38   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 110.38   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (346)
WDR76
Tbio
Novelty:  0.08744649
p_int:  1
Score:  0.544
Data Source:  BioPlex,STRINGDB
KBTBD8
Tbio
Novelty:  0.42601278
p_int:  0.999999957
p_ni:  4.2e-8
p_wrong:  1e-9
Score:  0.929
Data Source:  BioPlex,STRINGDB
CSPP1
Tbio
Novelty:  0.02734691
p_int:  0.99999972
p_ni:  2.8e-7
Score:  0.211
Data Source:  BioPlex,STRINGDB
VCPIP1
Tbio
Novelty:  0.09915033
p_int:  0.999993294
p_ni:  0.000006697
p_wrong:  9e-9
Data Source:  BioPlex
S100A4
Tchem
Novelty:  0.00136919
p_int:  0.999926879
p_ni:  0.000073121
Data Source:  BioPlex
VIM
Tbio
Novelty:  0.00030317
p_int:  0.998092133
p_ni:  0.001907867
Score:  0.906
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.995983085
p_ni:  0.004016893
p_wrong:  2.1e-8
Data Source:  BioPlex
INA
Tbio
Novelty:  0.00708581
p_int:  0.994434583
p_ni:  0.005565416
p_wrong:  1e-9
Score:  0.738
Data Source:  BioPlex,STRINGDB
CPEB1
Tbio
Novelty:  0.00444378
p_int:  0.990493192
p_ni:  0.009506808
Score:  0.177
Data Source:  BioPlex,STRINGDB
ZC3H13
Tbio
Novelty:  0.0990341
p_int:  0.986521228
p_ni:  0.001676675
p_wrong:  0.011802096
Score:  0.192
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
2
17
17
97.2
waist-hip ratio
1
15
15
97.1
waist circumference
1
6
6
88.4
hip circumference
1
5
5
88.3
BMI-adjusted waist circumference
1
2
2
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
17
97.2
waist-hip ratio
15
97.1
waist circumference
6
88.4
hip circumference
5
88.3
BMI-adjusted waist circumference
2
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gigaxonin
713996
Mouse
MGI:1890619
209239
Rat
RGD:1307766
307893
Dog
gigaxonin
VGNC:41105
489694
Horse
gigaxonin
VGNC:18240
100069891
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gigaxonin
Mouse
Rat
Dog
gigaxonin
Horse
gigaxonin
Publication Statistics
PubMed Score 110.38
PubMed score by year
PubTator Score 218.95
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title