GALNT3
Polypeptide N-acetylgalactosaminyltransferase 3
Protein Summary
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]
- ENST00000392701
- ENSP00000376465
- ENSG00000115339
- HHS
- HFTC
- HFTC1
- GalNAc-T3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.96 | ||
kinase perturbation | 0.81 | ||
histone modification site profile | 0.8 | ||
cellular component | 0.72 | ||
gene perturbation | 0.7 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.02 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 159 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 99.02 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 159 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (70)
RSPRY1
Novelty: 0.26883105
p_int: 0.962269275
p_ni: 3.64e-7
p_wrong: 0.037730361
Score: 0.204
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (17)
Reactome (14)
KEGG (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | FGFR3 ligand binding and activation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
FGFR3 ligand binding and activation | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (7)
Processes (5)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
bone density | 8 | 7 | 10 | 94.9 | |||||
1 | 1 | 1 | 52.4 | ||||||
intelligence | 2 | 2 | 1 | 6 | 34.9 | ||||
femoral neck bone mineral density | 1 | 1 | 1 | 14 | |||||
alkaline phosphatase measurement | 1 | 1 | 0 | 7 | 12 | ||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
bone density | 10 | 94.9 | |||||
1 | 52.4 | ||||||
intelligence | 1 | 6 | 34.9 | ||||
femoral neck bone mineral density | 1 | 14 | |||||
alkaline phosphatase measurement | 0 | 7 | 12 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | polypeptide N-acetylgalactosaminyltransferase 3 | VGNC:10819 | 459702 | |||||
Macaque | polypeptide N-acetylgalactosaminyltransferase 3 | 707605 | ||||||
Mouse | MGI:894695 | 14425 | ||||||
Rat | RGD:1306443 | 366061 | ||||||
Dog | polypeptide N-acetylgalactosaminyltransferase 3 | VGNC:41095 | 478774 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | polypeptide N-acetylgalactosaminyltransferase 3 | |||||
Macaque | polypeptide N-acetylgalactosaminyltransferase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | polypeptide N-acetylgalactosaminyltransferase 3 | |||||
Publication Statistics
PubMed Score 99.02
PubMed score by year
PubTator Score 78.87
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (40)
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0 of 0
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