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Tchem
GALNT14
Polypeptide N-acetylgalactosaminyltransferase 14

Protein Summary
Description
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays activity toward mucin-derived peptide substrates such as Muc2, Muc5AC, Muc7, and Muc13 (-58). May be involved in O-glycosylation in kidney. This gene encodes a Golgi protein which is a member of the polypeptide N-acetylgalactosaminyltransferase (ppGalNAc-Ts) protein family. These enzymes catalyze the transfer of N-acetyl-D-galactosamine (GalNAc) to the hydroxyl groups on serines and threonines in target peptides. The encoded protein has been shown to transfer GalNAc to large proteins like mucins. Alterations in this gene may play a role in cancer progression and response to chemotherapy. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324589
  • ENSP00000314500
  • ENSG00000158089
  • ENST00000349752
  • ENSP00000288988
  • ENST00000406653
  • ENSP00000385435

Symbol
  • GALNT15
  • GalNac-T10
  • GalNac-T14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.76
transcription factor perturbation
0.68
trait
0.61
transcription factor binding site profile
0.61
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.11   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.11   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (52)
MUC7
Tbio
Novelty:  0.00750654
Score:  0.977
Data Source:  STRINGDB
MUC5AC
Tbio
Novelty:  0.00074159
Score:  0.972
Data Source:  STRINGDB
MUC13
Tbio
Novelty:  0.01282861
Score:  0.972
Data Source:  STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.96
Data Source:  STRINGDB
MUC1
Tchem
Novelty:  0.00024203
Score:  0.948
Data Source:  STRINGDB
MUC6
Tbio
Novelty:  0.00304872
Score:  0.922
Data Source:  STRINGDB
MUC4
Tbio
Novelty:  0.00193208
Score:  0.921
Data Source:  STRINGDB
MUC12
Tbio
Novelty:  0.04323645
Score:  0.917
Data Source:  STRINGDB
MUC16
Tbio
Novelty:  0.00444587
Score:  0.914
Data Source:  STRINGDB
MUC5B
Tbio
Novelty:  0.000832
Score:  0.914
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
O-linked glycosylation of mucins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
O-linked glycosylation of mucins
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
5
4
6
98.8
platelet count
2
1
2
87.9
platelet crit
2
1
2
82.6
monocyte count
1
1
1
80.2
neutrophil count
2
3
4
78.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
6
98.8
platelet count
2
87.9
platelet crit
2
82.6
monocyte count
1
80.2
neutrophil count
4
78.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
polypeptide N-acetylgalactosaminyltransferase 14
705068
Mouse
MGI:1918935
71685
Rat
RGD:1310068
313878
Dog
polypeptide N-acetylgalactosaminyltransferase 14
VGNC:41089
483025
Horse
polypeptide N-acetylgalactosaminyltransferase 14
VGNC:18227
100070711
Species
Name
OMA
EggNOG
Inparanoid
Macaque
polypeptide N-acetylgalactosaminyltransferase 14
Mouse
Rat
Dog
polypeptide N-acetylgalactosaminyltransferase 14
Horse
polypeptide N-acetylgalactosaminyltransferase 14
Publication Statistics
PubMed Score 32.11
PubMed score by year
PubTator Score 19.30
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title