GALNT12
Polypeptide N-acetylgalactosaminyltransferase 12
Protein Summary
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward non-glycosylated peptides such as Muc5AC, Muc1a and EA2, and no detectable activity with Muc2 and Muc7. Displays enzymatic activity toward the Gal-NAc-Muc5AC glycopeptide, but no detectable activity to mono-GalNAc-glycosylated Muc1a, Muc2, Muc7 and EA2. May play an important role in the initial step of mucin-type oligosaccharide biosynthesis in digestive organs. This gene encodes a member of a family of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases, which catalyze the transfer of N-acetylgalactosamine (GalNAc) from UDP-GalNAc to a serine or threonine residue on a polypeptide acceptor in the initial step of O-linked protein glycosylation. Mutations in this gene are associated with an increased susceptibility to colorectal cancer.[provided by RefSeq, Mar 2011]
- ENST00000375011
- ENSP00000364150
- ENSG00000119514
- CRCS1
- GalNAc-T12
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.87 | ||
PubMedID | 0.75 | ||
histone modification site profile | 0.73 | ||
transcription factor perturbation | 0.68 | ||
tissue sample | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.91 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 81 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.91 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 81 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (84)
HPX
Novelty: 0.00138137
p_int: 0.997271471
p_ni: 0.002728509
p_wrong: 1.9e-8
Score: 0.304
Data Source: BioPlex,STRINGDB
MPPE1
Family: Enzyme
Novelty: 0.16027847
p_int: 0.988416274
p_ni: 0.011583721
p_wrong: 5e-9
Data Source: BioPlex
MGAT4C
Family: Enzyme
Novelty: 0.19680806
p_int: 0.98800922
p_ni: 0.01199077
p_wrong: 1e-8
Data Source: BioPlex
GALNT7
Family: Enzyme
Novelty: 0.05328171
p_int: 0.977625115
p_ni: 0.022374867
p_wrong: 1.8e-8
Score: 0.453
Data Source: BioPlex,STRINGDB
PTPRA
Family: Enzyme
Novelty: 0.01392344
p_int: 0.963251039
p_ni: 0.036748951
p_wrong: 1e-8
Data Source: BioPlex
LYPD4
Novelty: 0.00381728
p_int: 0.959936365
p_ni: 0.037296742
p_wrong: 0.002766892
Data Source: BioPlex
Nearest Tclin Targets
Pathways (11)
Reactome (8)
KEGG (2)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Reactome | Disease | ||||
Reactome | Diseases associated with O-glycosylation of proteins | ||||
Reactome | Diseases of glycosylation | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Defective GALNT12 causes colorectal cancer 1 (CRCS1) | ||||
Disease | ||||
Diseases associated with O-glycosylation of proteins | ||||
Diseases of glycosylation | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (3)
Components (3)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body mass index | 1 | 1 | 1 | 17.8 | |||||
FEV/FEC ratio | 1 | 1 | 1 | 11.6 | |||||
1 | 1 | 0 | 1.1 | 9 | |||||
serum galactose-deficient IgA1 measurement | 1 | 1 | 1 | 4.3 | |||||
1 | 1 | 0 | 1.1 | 0.5 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body mass index | 1 | 17.8 | |||||
FEV/FEC ratio | 1 | 11.6 | |||||
0 | 1.1 | 9 | |||||
serum galactose-deficient IgA1 measurement | 1 | 4.3 | |||||
0 | 1.1 | 0.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | polypeptide N-acetylgalactosaminyltransferase 12 | VGNC:13882 | 747531 | |||||
Macaque | polypeptide N-acetylgalactosaminyltransferase 12 | 715128 | ||||||
Mouse | MGI:2444664 | 230145 | ||||||
Rat | RGD:1562001 | 313233 | ||||||
Dog | polypeptide N-acetylgalactosaminyltransferase 12 | VGNC:41087 | 474777 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | polypeptide N-acetylgalactosaminyltransferase 12 | |||||
Macaque | polypeptide N-acetylgalactosaminyltransferase 12 | |||||
Mouse | ||||||
Rat | ||||||
Dog | polypeptide N-acetylgalactosaminyltransferase 12 | |||||
Publication Statistics
PubMed Score 12.91
PubMed score by year
PubTator Score 7.81
PubTator score by year
Related Publications
Text Mined References (13)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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