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Tbio
GALNS
N-acetylgalactosamine-6-sulfatase

Protein Summary
Description
This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268695
  • ENSP00000268695
  • ENSG00000141012

Symbol
  • GAS
  • MPS4A
  • GalN6S
  • GALNAC6S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
histone modification site profile
0.89
kinase perturbation
0.88
transcription factor binding site profile
0.74
disease perturbation
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226   (req: < 5)
Gene RIFs: 29   (req: <= 3)
Antibodies: 300   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 226   (req: >= 5)
Gene RIFs: 29   (req: > 3)
Antibodies: 300   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (167)
SUMF1
Tbio
Family:  Enzyme
Novelty:  0.00954537
p_int:  0.999980951
p_ni:  0.000019049
Score:  0.846
Data Source:  BioPlex,STRINGDB
ARSA
Tbio
Family:  Enzyme
Novelty:  0.00469851
p_int:  0.999627991
p_ni:  0.000372009
Score:  0.977
Data Source:  BioPlex,STRINGDB
DNASE2B
Tbio
Family:  Enzyme
Novelty:  0.02506932
p_int:  0.99828253
p_ni:  0.00171747
Data Source:  BioPlex
PRG3
Tbio
Novelty:  0.09431986
p_int:  0.998028515
p_ni:  0.001971485
Data Source:  BioPlex
POLE4
Tdark
Family:  Enzyme
Novelty:  0.23346084
p_int:  0.996907913
p_ni:  0.002992399
p_wrong:  0.000099688
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.994576183
p_ni:  0.005423816
Score:  0.196
Data Source:  BioPlex,STRINGDB
PLAUR
Tchem
Family:  Enzyme
Novelty:  0.00087642
p_int:  0.988940326
p_ni:  0.011059674
Score:  0.221
Data Source:  BioPlex,STRINGDB
LYZL1
Tbio
Family:  Enzyme
Novelty:  0.10945096
p_int:  0.985864886
p_ni:  0.014132179
p_wrong:  0.000002935
Data Source:  BioPlex
P2RX5
Tchem
Family:  IC
Novelty:  0.01591178
p_int:  0.978409924
p_ni:  0.021436677
p_wrong:  0.000153399
Data Source:  BioPlex
DPEP2
Tbio
Family:  Enzyme
Novelty:  0.14691384
p_int:  0.978347054
p_ni:  0.021652893
p_wrong:  5.3e-8
Score:  0.517
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
5
8
9
99.2
HbA1c measurement
6
10
11
98.8
mean corpuscular hemoglobin concentration
7
5
9
98.2
reticulocyte count
6
9
16
97.7
hematocrit
4
6
7
97.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
9
99.2
HbA1c measurement
11
98.8
mean corpuscular hemoglobin concentration
9
98.2
reticulocyte count
16
97.7
hematocrit
7
97.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galactosamine (N-acetyl)-6-sulfatase
VGNC:51575
736362
Macaque
galactosamine (N-acetyl)-6-sulfatase
697850
Mouse
MGI:1355303
50917
Rat
RGD:1565391
292073
Dog
galactosamine (N-acetyl)-6-sulfatase
VGNC:53388
489661
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galactosamine (N-acetyl)-6-sulfatase
Macaque
galactosamine (N-acetyl)-6-sulfatase
Mouse
Rat
Dog
galactosamine (N-acetyl)-6-sulfatase
Publication Statistics
PubMed Score 226.00
PubMed score by year
PubTator Score 392.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title