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Tbio
GALM
Aldose 1-epimerase

Protein Summary
Description
Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity). This gene encodes an enzyme that catalyzes the epimerization of hexose sugars such as glucose and galactose. The encoded protein is expressed in the cytoplasm and has a preference for galactose. The encoded protein may be required for normal galactose metabolism by maintaining the equilibrium of alpha and beta anomers of galactose.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272252
  • ENSP00000272252
  • ENSG00000143891

Symbol
  • GLAT
  • IBD1
  • BLOCK25
  • HEL-S-63p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
protein domain
0.73
cell type or tissue
0.69
histone modification site profile
0.69
small molecule perturbation
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 184   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 184   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (86)
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.806074569
p_ni:  0.193925359
p_wrong:  7.2e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
OR5F1
Tdark
Family:  oGPCR
Novelty:  13
p_int:  0.76540896
p_ni:  0.234591009
p_wrong:  3.1e-8
Score:  0.455
Data Source:  BioPlex,STRINGDB
GALK1
Tbio
Family:  Kinase
Novelty:  0.00156677
Score:  0.998
Data Source:  STRINGDB
GALE
Tchem
Family:  Enzyme
Novelty:  0.00256798
Score:  0.962
Data Source:  STRINGDB
LCT
Tbio
Family:  Enzyme
Novelty:  0.0019382
Score:  0.951
Data Source:  STRINGDB
AKR1B1
Tclin
Family:  Enzyme
Novelty:  0.00045769
Score:  0.928
Data Source:  STRINGDB
HK3
Tbio
Family:  Kinase
Novelty:  0.0151241
Score:  0.926
Data Source:  STRINGDB
GCK
Tchem
Family:  Kinase
Novelty:  0.00112778
Score:  0.924
Data Source:  STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.922
Data Source:  STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.919
Data Source:  STRINGDB
Pathways (7)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Glycolysis / Gluconeogenesis
KEGG
Metabolic pathways
KEGG
Galactose metabolism
Name
Explore in Pharos
Explore in Source
Glycolysis / Gluconeogenesis
Metabolic pathways
Galactose metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
10.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
10.3
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galactose mutarotase
VGNC:10657
459166
Macaque
galactose mutarotase [Source:HGNC Symbol;Acc:HGNC:24063]
Mouse
MGI:2442420
319625
Rat
RGD:1359459
313843
Dog
galactose mutarotase
VGNC:41083
483039
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galactose mutarotase
Macaque
galactose mutarotase [Source:HGNC Symbol;Acc:HGNC:24063]
Mouse
Rat
Dog
galactose mutarotase
Publication Statistics
PubMed Score 96.34
PubMed score by year
PubTator Score 36.35
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title