Tbio GAL Galanin peptides

Protein Summary

Description

Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P22466
• Q14413

Gene Name

• GAL

Ensembl ID

• ENST00000265643
• ENSP00000265643
• ENSG00000069482

Symbol

• GAL1
• GALN
• GLNN
• ETL8
• GALN
• GLNN
• GMAP
• GAL-GMAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
gene perturbation	0.99
transcription factor perturbation	0.74
small molecule perturbation	0.73
disease	0.72

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2149.76   (req: < 5)

Gene RIFs: 79   (req: <= 3)

Antibodies: 355   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2149.76   (req: >= 5)

Gene RIFs: 79   (req: > 3)

Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0