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Tbio
GAL
Galanin peptides

Protein Summary
Description
Endocrine hormone of the central and peripheral nervous systems that binds and activates the G protein-coupled receptors GALR1, GALR2, and GALR3. This small neuropeptide may regulate diverse physiologic functions including contraction of smooth muscle of the gastrointestinal and genitourinary tract, growth hormone and insulin release and adrenal secretion. This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265643
  • ENSP00000265643
  • ENSG00000069482

Symbol
  • GAL1
  • GALN
  • GLNN
  • ETL8
  • GALN
  • GLNN
  • GMAP
  • GAL-GMAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
gene perturbation
0.99
transcription factor perturbation
0.74
small molecule perturbation
0.73
disease
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2149.76   (req: < 5)
Gene RIFs: 70   (req: <= 3)
Antibodies: 355   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2149.76   (req: >= 5)
Gene RIFs: 70   (req: > 3)
Antibodies: 355   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (319)
MGAT4C
Tbio
Family:  Enzyme
Novelty:  0.19680806
p_int:  0.999985192
p_ni:  0.000002145
p_wrong:  0.000012664
Score:  0.272
Data Source:  BioPlex,STRINGDB
MMP10
Tchem
Novelty:  0.00112113
p_int:  0.999916822
p_ni:  0.000079412
p_wrong:  0.000003766
Score:  0.187
Data Source:  BioPlex,STRINGDB
FCGRT
Tclin
Novelty:  0.00105713
p_int:  0.999271637
p_ni:  0.0006478
p_wrong:  0.000080563
Data Source:  BioPlex
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
p_int:  0.99594704
p_ni:  0.004039696
p_wrong:  0.000013264
Data Source:  BioPlex
MICB
Tbio
Novelty:  0.00364639
p_int:  0.988477118
p_ni:  0.010137433
p_wrong:  0.001385449
Data Source:  BioPlex
HSPA5
Tchem
Novelty:  0.00043424
p_int:  0.982334773
p_ni:  0.017665227
Data Source:  BioPlex
CEACAM21
Tdark
Novelty:  0.46116153
p_int:  0.979796304
p_ni:  0.00006454
p_wrong:  0.020139156
Score:  0.179
Data Source:  BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty:  0.01080446
p_int:  0.960917724
p_ni:  0.000077436
p_wrong:  0.03900484
Data Source:  BioPlex
CSTL1
Tbio
Novelty:  0.13370814
p_int:  0.912933354
p_ni:  0.034807198
p_wrong:  0.052259448
Data Source:  BioPlex
ZMYND19
Tdark
Novelty:  0.3590069
p_int:  0.877668581
p_ni:  0.122322214
p_wrong:  0.000009204
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

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Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
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Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
2
4
5
97.9
appendicular lean mass
2
2
3
77.4
comparative body size at age 10, self-reported
1
1
1
64.4
mean corpuscular hemoglobin concentration
1
1
1
64.1
1
1
1
63.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
bone density
5
97.9
appendicular lean mass
3
77.4
comparative body size at age 10, self-reported
1
64.4
mean corpuscular hemoglobin concentration
1
64.1
1
63.6
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IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
galanin and GMAP prepropeptide
VGNC:10277
747508
Macaque
galanin and GMAP prepropeptide
721572
Mouse
MGI:95637
14419
Rat
RGD:61954
29141
Dog
galanin and GMAP prepropeptide
VGNC:41075
404001
Species
Name
OMA
EggNOG
Inparanoid
Chimp
galanin and GMAP prepropeptide
Macaque
galanin and GMAP prepropeptide
Mouse
Rat
Dog
galanin and GMAP prepropeptide
Publication Statistics
PubMed Score 2149.76
PubMed score by year
PubTator Score 202.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title