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Tbio
GADL1
Acidic amino acid decarboxylase GADL1

Protein Summary
Description
May catalyze the decarboxylation of L-aspartate, 3-sulfino-L-alanine (cysteine sulfinic acid), and L-cysteate to beta-alanine, hypotaurine and taurine, respectively. Does not exhibit any decarboxylation activity toward glutamate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282538
  • ENSP00000282538
  • ENSG00000144644
  • ENST00000454381
  • ENSP00000427059

Symbol
  • ADC
  • CSADC
  • HuADC
  • HuCSADC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
histone modification site profile
0.65
cellular component
0.64
trait
0.61
microRNA
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.46   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 54.46   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
OR10A4
Tbio
Family:  oGPCR
Novelty:  0.0796753
p_int:  0.999995055
p_ni:  0.000001321
p_wrong:  0.000003625
Data Source:  BioPlex
OR7A5
Tdark
Family:  oGPCR
Novelty:  1.72860482
p_int:  0.999975085
p_ni:  0.000024116
p_wrong:  7.98e-7
Data Source:  BioPlex
ANKMY2
Tdark
Novelty:  0.50777631
p_int:  0.999868711
p_ni:  0.000131289
Data Source:  BioPlex
RBM14
Tbio
Novelty:  0.01286049
p_int:  0.999168731
p_ni:  0.000830176
p_wrong:  0.000001093
Data Source:  BioPlex
PPP5C
Tbio
Family:  Enzyme
Novelty:  0.01990823
p_int:  0.850368967
p_ni:  0.149631033
Data Source:  BioPlex
ABAT
Tclin
Family:  Enzyme
Novelty:  0.0078359
Score:  0.963
Data Source:  STRINGDB
CDO1
Tbio
Family:  Enzyme
Novelty:  0.01682989
Score:  0.956
Data Source:  STRINGDB
ADO
Tbio
Family:  Enzyme
Novelty:  0.04529593
Score:  0.939
Data Source:  STRINGDB
ALDH7A1
Tbio
Family:  Enzyme
Novelty:  0.00069494
Score:  0.919
Data Source:  STRINGDB
CARNS1
Tbio
Family:  Enzyme
Novelty:  0.09322055
Score:  0.912
Data Source:  STRINGDB
Pathways (9)
Aspartate and asparagine metabolism (R-HSA-8963693)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aspartate and asparagine metabolism
Reactome
Degradation of cysteine and homocysteine
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Sulfur amino acid metabolism
Name
Explore in Pharos
Explore in Source
Aspartate and asparagine metabolism
Degradation of cysteine and homocysteine
Metabolism
Metabolism of amino acids and derivatives
Sulfur amino acid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
69.5
glomerular filtration rate
2
2
2
45.5
2
1
0
1.1
24.5
blood metabolite measurement
1
1
1
24.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
69.5
glomerular filtration rate
2
45.5
0
1.1
24.5
blood metabolite measurement
1
24.3
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glutamate decarboxylase like 1
VGNC:1823
470777
Macaque
glutamate decarboxylase like 1
706457
Mouse
MGI:1920998
73748
Dog
glutamate decarboxylase like 1
VGNC:41073
485629
Horse
glutamate decarboxylase like 1
VGNC:18210
100057562
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glutamate decarboxylase like 1
Macaque
glutamate decarboxylase like 1
Mouse
Dog
glutamate decarboxylase like 1
Horse
glutamate decarboxylase like 1
Publication Statistics
PubMed Score 54.46
PubMed score by year
PubTator Score 12.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title