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Tbio
GADD45GIP1
Growth arrest and DNA damage-inducible proteins-interacting protein 1

Protein Summary
Description
Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. This gene encodes a nuclear-localized protein that may be induced by p53 and regulates the cell cycle by inhibiting G1 to S phase progression. The encoded protein may interact with other cell cycle regulators. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316939
  • ENSP00000323065
  • ENSG00000179271

Symbol
  • MRPL59
  • PLINP1
  • PRG6
  • PRG6
  • CRIF1
  • PLINP
  • CKBBP2
  • Plinp1
  • MRP-L59
  • PLINP-1
  • CKbetaBP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.87
cell type or tissue
0.8
transcription factor perturbation
0.74
virus
0.66
tissue sample
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.38   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 144   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.38   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 144   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (156)
RPL37
Tbio
Novelty:  0.03935854
p_int:  0.99994705
p_ni:  0.00005295
Data Source:  BioPlex
MRPL18
Tbio
Novelty:  0.73438796
p_int:  0.999913486
p_ni:  0.000086514
Score:  0.99
Data Source:  BioPlex,STRINGDB
MRPL47
Tbio
Novelty:  0.05648009
p_int:  0.999909005
p_ni:  0.000090995
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL30
Tdark
Novelty:  1.03623556
p_int:  0.999563482
p_ni:  0.000436518
Score:  0.982
Data Source:  BioPlex,STRINGDB
EDC3
Tbio
Novelty:  0.02077346
p_int:  0.999524084
p_ni:  0.000475916
Data Source:  BioPlex
MRPL50
Tdark
Novelty:  0.88879319
p_int:  0.999412095
p_ni:  0.000587905
Score:  0.996
Data Source:  BioPlex,STRINGDB
MRPL53
Tdark
Novelty:  1.0076471
p_int:  0.999158383
p_ni:  0.000841617
Score:  0.984
Data Source:  BioPlex,STRINGDB
HECTD3
Tdark
Family:  Enzyme
Novelty:  2.20874654
p_int:  0.998788694
p_ni:  0.001211306
Data Source:  BioPlex
MRPL4
Tbio
Novelty:  0.27290276
p_int:  0.998724051
p_ni:  0.001275949
Score:  0.994
Data Source:  BioPlex,STRINGDB
MRPL42
Tbio
Novelty:  0.48241447
p_int:  0.998707342
p_ni:  0.001292658
Score:  0.994
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (43)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin
3
4
4
95.9
cortical surface area measurement
2
3
0
17.5
95.5
reticulocyte count
7
4
8
93.9
red blood cell distribution width
3
3
4
92.5
erythrocyte count
5
7
7
91.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin
4
95.9
cortical surface area measurement
0
17.5
95.5
reticulocyte count
8
93.9
red blood cell distribution width
4
92.5
erythrocyte count
7
91.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GADD45G interacting protein 1
VGNC:3634
747626
Mouse
MGI:1914947
102060
Rat
RGD:1309249
288916
Dog
GADD45G interacting protein 1
VGNC:41072
476693
Cow
GADD45G interacting protein 1
VGNC:29209
504718
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GADD45G interacting protein 1
Mouse
Rat
Dog
GADD45G interacting protein 1
Cow
GADD45G interacting protein 1
Publication Statistics
PubMed Score 46.38
PubMed score by year
PubTator Score 14.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title