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Tbio
GADD45B
Growth arrest and DNA damage-inducible protein GADD45 beta

Protein Summary
Description
Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK. This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The genes in this group respond to environmental stresses by mediating activation of the p38/JNK pathway. This activation is mediated via their proteins binding and activating MTK1/MEKK4 kinase, which is an upstream activator of both p38 and JNK MAPKs. The function of these genes or their protein products is involved in the regulation of growth and apoptosis. These genes are regulated by different mechanisms, but they are often coordinately expressed and can function cooperatively in inhibiting cell growth. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215631
  • ENSP00000215631
  • ENSG00000099860

Symbol
  • MYD118
  • MYD118
  • GADD45BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.99
transcription factor perturbation
0.99
transcription factor binding site profile
0.97
disease perturbation
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.26   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 187.26   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
MAP3K4
Tbio
Family:  Kinase
Novelty:  0.02186397
p_int:  1
Score:  0.983
Data Source:  BioPlex,STRINGDB
CNOT2
Tbio
Novelty:  0.01886737
p_int:  0.999639365
p_ni:  0.000360635
Score:  0.558
Data Source:  BioPlex,STRINGDB
CNOT6
Tbio
Novelty:  0.03605299
p_int:  0.99943992
p_ni:  0.00056008
Score:  0.747
Data Source:  BioPlex,STRINGDB
IL36A
Tbio
Novelty:  0.03569425
p_int:  0.999407411
p_ni:  0.000592589
Score:  0.211
Data Source:  BioPlex,STRINGDB
CNOT6L
Tbio
Novelty:  0.06038336
p_int:  0.999331931
p_ni:  0.000668069
Score:  0.549
Data Source:  BioPlex,STRINGDB
CNOT8
Tbio
Novelty:  0.01700084
p_int:  0.999030141
p_ni:  0.000969859
Score:  0.54
Data Source:  BioPlex,STRINGDB
CNOT11
Tbio
Novelty:  0.01687183
p_int:  0.999018231
p_ni:  0.000981769
Score:  0.807
Data Source:  BioPlex,STRINGDB
CNOT1
Tbio
Novelty:  0.00362753
p_int:  0.997512871
p_ni:  0.002487129
Score:  0.787
Data Source:  BioPlex,STRINGDB
CNOT10
Tdark
Novelty:  0.30195594
p_int:  0.997106393
p_ni:  0.002893607
Score:  0.787
Data Source:  BioPlex,STRINGDB
CNOT9
Tbio
Novelty:  0.05592835
p_int:  0.995473451
p_ni:  0.004526549
Score:  0.6
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (37)
Find Similar Targets
Items per page:
1 – 5 of 23
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Non-small cell lung cancer
KEGG
Chronic myeloid leukemia
KEGG
Gastric cancer
KEGG
Melanoma
KEGG
Cell cycle
Name
Explore in Pharos
Explore in Source
Non-small cell lung cancer
Chronic myeloid leukemia
Gastric cancer
Melanoma
Cell cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
1
2
78.1
age-related hearing impairment
1
1
0
5.9
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
78.1
age-related hearing impairment
0
5.9
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
growth arrest and DNA damage inducible beta
711257
Mouse
MGI:107776
17873
Rat
RGD:1309080
299626
Dog
growth arrest and DNA damage inducible beta
VGNC:41070
485069
Horse
growth arrest and DNA damage inducible beta
VGNC:18208
100059768
Species
Name
OMA
EggNOG
Inparanoid
Macaque
growth arrest and DNA damage inducible beta
Mouse
Rat
Dog
growth arrest and DNA damage inducible beta
Horse
growth arrest and DNA damage inducible beta
Publication Statistics
PubMed Score 187.26
PubMed score by year
PubTator Score 81.31
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title