Tbio GAD1 Glutamate decarboxylase 1

Protein Summary

Description

Catalyzes the production of GABA. This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q99259
• Q49AK1
• Q53TQ7
• Q9BU91
• Q9UHH4

Gene Name

• GAD1

Ensembl ID

• ENST00000344257
• ENSP00000341167
• ENSG00000128683
• ENST00000358196
• ENSP00000350928
• ENST00000375272
• ENSP00000364421
• ENST00000493875
• ENSP00000434696
• ENST00000625689
• ENSP00000486612

Symbol

• GAD
• GAD67
• GAD
• SCP
• CPSQ1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
phosphatase	0.98
PubMedID	0.98
transcription factor perturbation	0.88
transcription factor	0.83
transcription factor binding site profile	0.82

Protein Classes

PANTHER Classes

Protein / Lyase / Decarboxylase / Glutamate Decarboxylase 1

DTO Classes

Protein / Enzyme / Lyase / Decarboxylase / Glutamate Decarboxylase 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1731.36   (req: < 5)

Gene RIFs: 105   (req: <= 3)

Antibodies: 668   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1731.36   (req: >= 5)

Gene RIFs: 105   (req: > 3)

Antibodies: 668   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0