GABRR1
Gamma-aminobutyric acid receptor subunit rho-1
Protein Summary
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. GABRR1 is a member of the rho subunit family. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
- ENST00000369451
- ENSP00000358463
- ENSG00000146276
- ENST00000435811
- ENSP00000394687
- ENST00000454853
- ENSP00000412673
- ENST00000611484
- ENSP00000478846
- ENST00000621627
- ENSP00000481986
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.92 | ||
molecular function | 0.86 | ||
cell type or tissue | 0.78 | ||
drug | 0.77 | ||
kinase | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.43 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 196 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 62.43 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 196 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 2