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Tclin
GABRG3
Gamma-aminobutyric acid receptor subunit gamma-3

Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. The protein encoded by this gene is a gamma subunit, which contains the benzodiazepine binding site. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000555083
  • ENSP00000452244
  • ENSG00000182256
  • ENST00000615808
  • ENSP00000479113
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
protein domain
0.92
molecular function
0.86
cell type or tissue
0.81
trait
0.75


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.89   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.89   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 18
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (18)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (100)
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
Score:  0.942
Data Source:  Reactome,STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.94
Data Source:  Reactome,STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.94
Data Source:  Reactome,STRINGDB
GABRQ
Tclin
Family:  IC
Novelty:  0.12221217
Score:  0.938
Data Source:  Reactome,STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.913
Data Source:  STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.913
Data Source:  Reactome,STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.911
Data Source:  STRINGDB
GABRA2
Tclin
Family:  IC
Novelty:  0.00663529
Score:  0.911
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.909
Data Source:  STRINGDB
ARHGEF9
Tbio
Novelty:  0.01577146
Score:  0.909
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
GABA receptor activation (R-HSA-977443)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (27)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
6
1
9
88.6
sleep duration
2
1
2
86.9
serum metabolite measurement
2
1
8
86.9
total cholesterol measurement
3
1
3
2.7
84.6
triglyceride measurement
5
1
6
84.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
9
88.6
sleep duration
2
86.9
serum metabolite measurement
8
86.9
total cholesterol measurement
3
2.7
84.6
triglyceride measurement
6
84.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor gamma3 subunit
720390
Mouse
MGI:95624
14407
Rat
RGD:621735
79211
Horse
gamma-aminobutyric acid type A receptor gamma3 subunit [Source:HGNC Symbol;Acc:HGNC:4088]
Opossum
gamma-aminobutyric acid receptor subunit gamma-3
100011485
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor gamma3 subunit
Mouse
Rat
Horse
gamma-aminobutyric acid type A receptor gamma3 subunit [Source:HGNC Symbol;Acc:HGNC:4088]
Opossum
gamma-aminobutyric acid receptor subunit gamma-3
Publication Statistics
PubMed Score 19.89
PubMed score by year
PubTator Score 11.07
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title