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Tclin
GABRG1
Gamma-aminobutyric acid receptor subunit gamma-1

Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. The protein encoded by this gene belongs to the ligand-gated ionic channel family. It is an integral membrane protein and plays an important role in inhibiting neurotransmission by binding to the benzodiazepine receptor and opening an integral chloride channel. This gene is clustered with three other family members on chromosome 4. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295452
  • ENSP00000295452
  • ENSG00000163285
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
gene perturbation
0.97
molecular function
0.93
protein domain
0.92
microRNA
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.56   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 126   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.56   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 126   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 14
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (14)
halothane
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isoflurane
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desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
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thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (182)
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.845
Data Source:  BioPlex,STRINGDB
GABRD
Tclin
Family:  IC
Novelty:  0.0204242
Score:  0.838
Data Source:  STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.835
Data Source:  STRINGDB
GPHN
Tbio
Novelty:  0.0020752
Score:  0.822
Data Source:  STRINGDB
GABARAP
Tbio
Novelty:  0.00444901
Score:  0.82
Data Source:  STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.8
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.79
Data Source:  STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.777
Data Source:  STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.746
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.743
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Retrograde endocannabinoid signaling
KEGG
GABAergic synapse
KEGG
Nicotine addiction
KEGG
Neuroactive ligand-receptor interaction
KEGG
Morphine addiction
Name
Explore in Pharos
Explore in Source
Retrograde endocannabinoid signaling
GABAergic synapse
Nicotine addiction
Neuroactive ligand-receptor interaction
Morphine addiction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
2.7
49.4
risk-taking behaviour
1
1
1
13.4
self reported educational attainment
1
1
1
1.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.7
49.4
risk-taking behaviour
1
13.4
self reported educational attainment
1
1.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor gamma1 subunit
VGNC:7418
471393
Macaque
gamma-aminobutyric acid type A receptor gamma1 subunit
703792
Mouse
MGI:103156
14405
Rat
RGD:621732
140674
Dog
gamma-aminobutyric acid type A receptor gamma1 subunit
VGNC:41063
100856619
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor gamma1 subunit
Macaque
gamma-aminobutyric acid type A receptor gamma1 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor gamma1 subunit
Publication Statistics
PubMed Score 20.56
PubMed score by year
PubTator Score 13.92
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title