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Tclin
GABRE
Gamma-aminobutyric acid receptor subunit epsilon

Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. The product of this gene belongs to the ligand-gated ionic channel (TC 1.A.9) family. It encodes the gamma-aminobutyric acid (GABA) A receptor which is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes an epsilon subunit. It is mapped to chromosome Xq28 in a cluster comprised of genes encoding alpha 3, beta 4 and theta subunits of the same receptor. Alternatively spliced transcript variants have been identified, but only one is thought to encode a protein. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370328
  • ENSP00000359353
  • ENSG00000102287
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.86
protein domain
0.85
tissue sample
0.64
tissue
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.2   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 212   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.2   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 212   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 10
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (10)
halothane
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isoflurane
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desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
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triclofos
Rendered image for triclofos
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
HMBS
Tbio
Family:  Enzyme
Novelty:  0.00193847
p_int:  0.999890082
p_ni:  0.000109918
Score:  0.303
Data Source:  BioPlex,STRINGDB
ERMP1
Tbio
Family:  Enzyme
Novelty:  0.16736317
p_int:  0.997145264
p_ni:  0.002854736
Data Source:  BioPlex
ALG9
Tbio
Family:  Enzyme
Novelty:  0.02975572
p_int:  0.996089577
p_ni:  0.003910422
p_wrong:  1e-9
Score:  0.333
Data Source:  BioPlex,STRINGDB
KCNQ5
Tclin
Family:  IC
Novelty:  0.01271842
p_int:  0.991682542
p_ni:  0.000414641
p_wrong:  0.007902817
Score:  0.189
Data Source:  BioPlex,STRINGDB
ENTPD4
Tbio
Family:  Enzyme
Novelty:  0.11023026
p_int:  0.977945277
p_ni:  0.000160259
p_wrong:  0.021894465
Score:  0.197
Data Source:  BioPlex,STRINGDB
EPHB4
Tchem
Family:  Kinase
Novelty:  0.00422975
p_int:  0.977830344
p_ni:  0.022169655
p_wrong:  1e-9
Data Source:  BioPlex
BSCL2
Tbio
Novelty:  0.00483959
p_int:  0.974338837
p_ni:  0.025661163
Data Source:  BioPlex
TTC17
Tdark
Novelty:  0.79373597
p_int:  0.963435531
p_ni:  0.036564469
Data Source:  BioPlex
MIA3
Tbio
Novelty:  0.02784348
p_int:  0.955285719
p_ni:  0.044714281
Data Source:  BioPlex
GRAMD1A
Tbio
Novelty:  0.15461113
p_int:  0.937698338
p_ni:  0.062301662
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Retrograde endocannabinoid signaling
KEGG
GABAergic synapse
KEGG
Nicotine addiction
KEGG
Neuroactive ligand-receptor interaction
KEGG
Morphine addiction
Name
Explore in Pharos
Explore in Source
Retrograde endocannabinoid signaling
GABAergic synapse
Nicotine addiction
Neuroactive ligand-receptor interaction
Morphine addiction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor epsilon subunit
VGNC:12364
107971226
Macaque
gamma-aminobutyric acid type A receptor epsilon subunit
704693
Mouse
MGI:1330235
14404
Dog
gamma-aminobutyric acid type A receptor epsilon subunit
VGNC:41062
492220
Horse
gamma-aminobutyric acid type A receptor epsilon subunit
VGNC:18200
100069261
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor epsilon subunit
Macaque
gamma-aminobutyric acid type A receptor epsilon subunit
Mouse
Dog
gamma-aminobutyric acid type A receptor epsilon subunit
Horse
gamma-aminobutyric acid type A receptor epsilon subunit
Publication Statistics
PubMed Score 24.20
PubMed score by year
PubTator Score 12.66
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title