GABRB3
Gamma-aminobutyric acid receptor subunit beta-3
Protein Summary
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript ...more
- ENST00000299267
- ENSP00000299267
- ENSG00000166206
- ENST00000311550
- ENSP00000308725
- ENST00000400188
- ENSP00000383049
- ENST00000545868
- ENSP00000439169
- ENST00000622697
- ENSP00000481004
- ENST00000628124
- ENSP00000486819
- ENST00000636466
- ENSP00000489768
- ECA5
- EIEE43
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
molecular function | 0.91 | ||
protein domain | 0.85 | ||
disease | 0.75 | ||
transcription factor perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.95 (req: < 5)
Gene RIFs: 71 (req: <= 3)
Antibodies: 306 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 242.95 (req: >= 5)
Gene RIFs: 71 (req: > 3)
Antibodies: 306 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 18
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 35