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Tclin
GABRB3
Gamma-aminobutyric acid receptor subunit beta-3

Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. This gene encodes a member of the ligand-gated ionic channel family. The encoded protein is one the subunits of a multi-subunit chloride channel that serves as the receptor for gamma-aminobutyric acid, a major inhibitory neurotransmitter of the mammalian nervous system. This gene is located on the long arm of chromosome 15 in a cluster with two other genes encoding related subunits of the family. This gene may be associated with the pathogenesis of several disorders including Angelman syndrome, Prader-Willi syndrome, nonsyndromic orofacial clefts, epilepsy and autism. Alternatively spliced transcript ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299267
  • ENSP00000299267
  • ENSG00000166206
  • ENST00000311550
  • ENSP00000308725
  • ENST00000400188
  • ENSP00000383049
  • ENST00000545868
  • ENSP00000439169
  • ENST00000622697
  • ENSP00000481004
  • ENST00000628124
  • ENSP00000486819
  • ENST00000636466
  • ENSP00000489768

Symbol
  • ECA5
  • EIEE43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
molecular function
0.91
protein domain
0.85
disease
0.75
transcription factor perturbation
0.74


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.43   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 208.43   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 35
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (35)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
Protein-Protein Interactions (152)
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
p_int:  0.999999792
p_ni:  8e-9
p_wrong:  2e-7
Score:  0.916
Data Source:  BioPlex,Reactome,STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
p_int:  0.999966604
p_ni:  0.000033396
Score:  0.967
Data Source:  BioPlex,STRINGDB
CHRNB4
Tclin
Family:  IC
Novelty:  0.01151716
p_int:  0.999871347
p_ni:  0.000121053
p_wrong:  0.0000076
Data Source:  BioPlex
MCOLN3
Tchem
Family:  IC
Novelty:  0.03209262
p_int:  0.999536364
p_ni:  0.000454116
p_wrong:  0.000009519
Score:  0.177
Data Source:  BioPlex,STRINGDB
ASIC4
Tbio
Family:  IC
Novelty:  0.02912816
p_int:  0.995680473
p_ni:  0.004280796
p_wrong:  0.000038731
Score:  0.215
Data Source:  BioPlex,STRINGDB
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.984
Data Source:  Reactome,STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.981
Data Source:  STRINGDB
GABRA1
Tclin
Family:  IC
Novelty:  0.0094079
Score:  0.979
Data Source:  Reactome,STRINGDB
GABRA3
Tclin
Family:  IC
Novelty:  0.02180091
Score:  0.96
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.96
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (19)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
2
2
75.4
mathematical ability
1
2
2
65.7
cognitive function measurement
1
1
1
49.5
Hepatitis
1
1
0
1
27.3
body mass index
1
1
1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
2
75.4
mathematical ability
2
65.7
cognitive function measurement
1
49.5
Hepatitis
0
1
27.3
body mass index
1
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor beta3 subunit
VGNC:7537
453265
Macaque
gamma-aminobutyric acid type A receptor beta3 subunit
711754
Mouse
MGI:95621
14402
Rat
RGD:2651
24922
Dog
gamma-aminobutyric acid type A receptor beta3 subunit
VGNC:41060
606913
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor beta3 subunit
Macaque
gamma-aminobutyric acid type A receptor beta3 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor beta3 subunit
Publication Statistics
PubMed Score 208.43
PubMed score by year
PubTator Score 124.05
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title