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Tclin
GABRA3
Gamma-aminobutyric acid receptor subunit alpha-3

Protein Summary
Description
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. At least 16 distinct subunits of GABA-A receptors have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370314
  • ENSP00000359337
  • ENSG00000011677
  • ENST00000535043
  • ENSP00000443527
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.96
protein domain
0.92
gene perturbation
0.91
molecular function
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.63   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.63   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 28
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (28)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
triclofos
Rendered image for triclofos
Protein-Protein Interactions (122)
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
p_int:  0.999999941
p_wrong:  5.9e-8
Score:  0.937
Data Source:  BioPlex,STRINGDB
ABCA7
Tbio
Family:  Transporter
Novelty:  0.00808369
p_int:  0.998360459
p_ni:  0.001347275
p_wrong:  0.000292265
Score:  0.195
Data Source:  BioPlex,STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.997889371
p_ni:  0.000931606
p_wrong:  0.001179022
Score:  0.223
Data Source:  BioPlex,STRINGDB
TMEM131
Tdark
Novelty:  0.02152783
p_int:  0.99352543
p_ni:  0.00647457
Data Source:  BioPlex
GLRB
Tclin
Family:  IC
Novelty:  0.01721113
p_int:  0.993368449
p_ni:  0.006576581
p_wrong:  0.00005497
Score:  0.642
Data Source:  BioPlex,STRINGDB
TUSC3
Tbio
Novelty:  0.01388722
p_int:  0.991217702
p_ni:  0.008652115
p_wrong:  0.000130183
Score:  0.152
Data Source:  BioPlex,STRINGDB
AMIGO1
Tbio
Novelty:  0.00864791
p_int:  0.981583319
p_ni:  0.018395603
p_wrong:  0.000021079
Data Source:  BioPlex
TMEM59L
Tbio
Novelty:  0.22745646
p_int:  0.978260685
p_ni:  0.01948075
p_wrong:  0.002258566
Score:  0.248
Data Source:  BioPlex,STRINGDB
TTC17
Tdark
Novelty:  0.79373597
p_int:  0.967403573
p_ni:  0.032596427
Data Source:  BioPlex
EDA
Tbio
Novelty:  0.00352464
p_int:  0.965038662
p_ni:  0.009515138
p_wrong:  0.0254462
Score:  0.216
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor alpha3 subunit
711230
Mouse
MGI:95615
14396
Rat
RGD:2648
24947
Dog
gamma-aminobutyric acid type A receptor alpha3 subunit
VGNC:41055
492223
Horse
gamma-aminobutyric acid type A receptor alpha3 subunit
VGNC:18193
100063420
Species
Name
OMA
EggNOG
Inparanoid
Macaque
gamma-aminobutyric acid type A receptor alpha3 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor alpha3 subunit
Horse
gamma-aminobutyric acid type A receptor alpha3 subunit
Publication Statistics
PubMed Score 47.63
PubMed score by year
PubTator Score 34.54
PubTator score by year
Patents
Patents by year
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Related Publications
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0 of 0
PMID
Year
Title