GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1
Protein Summary
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the sa ...more
- ENST00000023897
- ENSP00000023897
- ENSG00000022355
- ENST00000393943
- ENSP00000377517
- ENST00000428797
- ENSP00000393097
- ENST00000437025
- ENSP00000415441
- ENST00000635880
- ENSP00000489738
- ENST00000636573
- ENSP00000490320
- ENST00000637827
- ENSP00000490804
- ENST00000638112
- ENSP00000489839
- EJM
- ECA4
- EJM5
- EIEE19
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
ligand (chemical) | 0.97 | ||
chemical | 0.94 | ||
protein domain | 0.92 | ||
molecular function | 0.9 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.17 (req: < 5)
Gene RIFs: 107 (req: <= 3)
Antibodies: 442 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 123.17 (req: >= 5)
Gene RIFs: 107 (req: > 3)
Antibodies: 442 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 85
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 51