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Tclin
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1

Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the sa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000023897
  • ENSP00000023897
  • ENSG00000022355
  • ENST00000393943
  • ENSP00000377517
  • ENST00000428797
  • ENSP00000393097
  • ENST00000437025
  • ENSP00000415441
  • ENST00000635880
  • ENSP00000489738
  • ENST00000636573
  • ENSP00000490320
  • ENST00000637827
  • ENSP00000490804
  • ENST00000638112
  • ENSP00000489839

Symbol
  • EJM
  • ECA4
  • EJM5
  • EIEE19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.97
chemical
0.94
protein domain
0.92
molecular function
0.9


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.9   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.9   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 85
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 51
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (51)
halothane
Rendered image for halothane
isoflurane
Rendered image for isoflurane
topiramate
Rendered image for topiramate
desflurane
Rendered image for desflurane
sevoflurane
Rendered image for sevoflurane
methoxyflurane
Rendered image for methoxyflurane
halazepam
Rendered image for halazepam
metharbital
Rendered image for metharbital
talbutal
Rendered image for talbutal
thiamylal
Rendered image for thiamylal
Protein-Protein Interactions (195)
GABRG2
Tclin
Family:  IC
Novelty:  0.00819163
Score:  0.991
Data Source:  Reactome,STRINGDB
GABRB2
Tclin
Family:  IC
Novelty:  0.01954146
Score:  0.988
Data Source:  Reactome,STRINGDB
GABRB3
Tclin
Family:  IC
Novelty:  0.00485997
Score:  0.979
Data Source:  Reactome,STRINGDB
GABRB1
Tclin
Family:  IC
Novelty:  0.02895574
Score:  0.978
Data Source:  Reactome,STRINGDB
GPHN
Tbio
Novelty:  0.0020752
Score:  0.961
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.954
Data Source:  STRINGDB
GABRA4
Tclin
Family:  IC
Novelty:  0.03089903
Score:  0.947
Data Source:  STRINGDB
GABRA5
Tclin
Family:  IC
Novelty:  0.01499706
Score:  0.939
Data Source:  STRINGDB
GABRQ
Tclin
Family:  IC
Novelty:  0.12221217
Score:  0.939
Data Source:  Reactome,STRINGDB
DNM1
Tbio
Novelty:  0.00319082
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
GABA receptor activation (R-HSA-977443)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor alpha1 subunit
VGNC:8618
462241
Macaque
gamma-aminobutyric acid type A receptor alpha1 subunit
574302
Mouse
MGI:95613
14394
Rat
RGD:61855
29705
Dog
gamma-aminobutyric acid type A receptor alpha1 subunit
VGNC:41053
489143
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid type A receptor alpha1 subunit
Macaque
gamma-aminobutyric acid type A receptor alpha1 subunit
Mouse
Rat
Dog
gamma-aminobutyric acid type A receptor alpha1 subunit
Publication Statistics
PubMed Score 99.90
PubMed score by year
PubTator Score 81.55
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title