Tbio GABPB1 GA-binding protein subunit beta-1

Protein Summary

Description

Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene. This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q06547
• A8IE52
• Q06545
• Q12940
• Q12941
• Q12942
• Q8IYD0
• GABP subunit beta-1

Gene Name

• GABPB1

Ensembl ID

• ENST00000220429
• ENSP00000220429
• ENSG00000104064
• ENST00000359031
• ENSP00000351923
• ENST00000380877
• ENSP00000370259
• ENST00000396464
• ENSP00000379728
• ENST00000429662
• ENSP00000395771

Symbol

• E4TF1B
• GABPB
• GABPB2
• E4TF1
• GABPB
• BABPB2
• E4TF1B
• GABPB2
• NRF2B1
• NRF2B2
• GABPB-1
• E4TF1-47
• E4TF1-53

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
virus perturbation	0.94
transcription factor binding site profile	0.87
trait	0.86
disease perturbation	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.06   (req: < 5)

Gene RIFs: 21   (req: <= 3)

Antibodies: 297   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.06   (req: >= 5)

Gene RIFs: 21   (req: > 3)

Antibodies: 297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0