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Tclin
GABBR1
Gamma-aminobutyric acid type B receptor subunit 1

Protein Summary
Description
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed:9872316, PubMed:9872744, PubMed:15617512, PubMed:18165688, PubMed:22660477, PubMed:24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed:18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed:10906333, PubMed:10773016, PubMed:10075644, PubMed:9872744, PubMed:24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis (PubMed:10075644). Calcium is required for high affinity binding to GABA (By similarity). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed:9844003). Pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355973
  • ENSP00000348248
  • ENSG00000204681
  • ENST00000376977
  • ENSP00000366176
  • ENST00000377012
  • ENSP00000366211
  • ENST00000377016
  • ENSP00000366215
  • ENST00000377034
  • ENSP00000366233
  • ENST00000383537
  • ENSP00000373029
  • ENSG00000206466
  • ENST00000383541
  • ENSP00000373033
  • ENST00000383542
  • ENSP00000373034
  • ENST00000383543
  • ENSP00000373035
  • ENST00000383636
  • ENSP00000373132
  • ENSG00000206511
  • ENST00000383637
  • ENSP00000373133
  • ENST00000383638
  • ENSP00000373134
  • ENST00000383639
  • ENSP00000373135
  • ENST00000414980
  • ENSP00000406499
  • ENSG00000232632
  • ENST00000417759
  • ENSP00000391572
  • ENSG00000237112
  • ENST00000419674
  • ENSP00000399861
  • ENSG00000232569
  • ENST00000423604
  • ENSP00000388035
  • ENST00000425097
  • ENSP00000411286
  • ENST00000434660
  • ENSP00000412167
  • ENST00000438094
  • ENSP00000406285
  • ENST00000439457
  • ENSP00000406066
  • ENST00000443440
  • ENSP00000399318
  • ENST00000446436
  • ENSP00000394528
  • ENST00000448754
  • ENSP00000405709
  • ENSG00000237051
  • ENST00000449163
  • ENSP00000411263
  • ENST00000452300
  • ENSP00000408938
  • ENST00000458612
  • ENSP00000416903
  • ENST00000494877
  • ENSP00000419061
  • ENST00000546913
  • ENSP00000448999
  • ENST00000547410
  • ENSP00000448531
  • ENST00000548767
  • ENSP00000446983
  • ENST00000551140
  • ENSP00000448654
  • ENST00000551423
  • ENSP00000449342
  • ENST00000552399
  • ENSP00000449449

Symbol
  • GPRC3A
  • GB1
  • GPRC3A
  • GABABR1
  • GABBR1-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.92
hub protein
0.85
protein domain
0.85
phenotype
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1287.58   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1287.58   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3