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Tbio
GABARAPL1
Gamma-aminobutyric acid receptor-associated protein-like 1

Protein Summary
Description
Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266458
  • ENSP00000266458
  • ENSG00000139112
  • ENST00000421801
  • ENSP00000411256
  • ENST00000543602
  • ENSP00000445857
  • ENST00000545887
  • ENSP00000444186

Symbol
  • GEC1
  • ATG8
  • GEC1
  • APG8L
  • ATG8B
  • ATG8L
  • APG8-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.98
transcription factor perturbation
0.98
kinase perturbation
0.91
small molecule perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.35   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 573.35   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0