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Tbio
GABARAPL1
Gamma-aminobutyric acid receptor-associated protein-like 1

Protein Summary
Description
Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266458
  • ENSP00000266458
  • ENSG00000139112
  • ENST00000421801
  • ENSP00000411256
  • ENST00000543602
  • ENSP00000445857
  • ENST00000545887
  • ENSP00000444186

Symbol
  • GEC1
  • ATG8
  • GEC1
  • APG8L
  • ATG8B
  • ATG8L
  • APG8-LIKE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.98
transcription factor perturbation
0.98
kinase perturbation
0.91
small molecule perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.6   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 483.6   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (203)
ATG4C
Tbio
Family:  Enzyme
Novelty:  0.04175533
p_int:  0.999999894
p_ni:  4.2e-8
p_wrong:  6.4e-8
Score:  0.979
Data Source:  BioPlex,STRINGDB
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.999999775
p_ni:  1.5e-8
p_wrong:  2.1e-7
Score:  0.839
Data Source:  BioPlex,STRINGDB
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999997544
p_ni:  5.7e-8
p_wrong:  0.000002399
Score:  0.162
Data Source:  BioPlex,STRINGDB
TBC1D25
Tbio
Novelty:  0.06756361
p_int:  0.999696572
p_ni:  2.64e-7
p_wrong:  0.000303164
Score:  0.792
Data Source:  BioPlex,STRINGDB
NSMAF
Tbio
Novelty:  0.08595515
p_int:  0.992717692
p_ni:  0.000001531
p_wrong:  0.007280777
Score:  0.492
Data Source:  BioPlex,STRINGDB
ATG7
Tchem
Novelty:  0.00120728
Score:  0.999
Data Source:  STRINGDB
ATG3
Tbio
Novelty:  0.00541077
Score:  0.998
Data Source:  STRINGDB
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
Score:  0.997
Data Source:  STRINGDB
ATG5
Tbio
Novelty:  0.00081472
Score:  0.995
Data Source:  STRINGDB
ATG12
Tbio
Novelty:  0.00304298
Score:  0.995
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
Pathways (12)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lectin-like oxidized LDL receptor 1 measurement
1
1
1
70.2
self reported educational attainment
1
1
1
2.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lectin-like oxidized LDL receptor 1 measurement
1
70.2
self reported educational attainment
1
2.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid receptor-associated protein-like 3
467760
Macaque
GABA type A receptor associated protein like 1
717640
Mouse
MGI:1914980
57436
Rat
RGD:1596143
689161
Dog
GABA type A receptor associated protein like 1
612919
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gamma-aminobutyric acid receptor-associated protein-like 3
Macaque
GABA type A receptor associated protein like 1
Mouse
Rat
Dog
GABA type A receptor associated protein like 1
Publication Statistics
PubMed Score 483.60
PubMed score by year
PubTator Score 161.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title