You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GABARAP
Gamma-aminobutyric acid receptor-associated protein

Protein Summary
Description
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302386
  • ENSP00000306866
  • ENSG00000170296

Symbol
  • FLC3B
  • MM46
  • ATG8A
  • GABARAP-a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
disease perturbation
0.96
kinase perturbation
0.96
cellular component
0.95
interacting protein
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.56   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 593   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 233.56   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 593   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (170)
PI4K2A
Tbio
Family:  Kinase
Novelty:  0.03506675
p_int:  0.999994995
p_ni:  0.000004921
p_wrong:  8.4e-8
Score:  0.181
Data Source:  BioPlex,STRINGDB
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.99998516
p_ni:  0.000014838
p_wrong:  2e-9
Score:  0.557
Data Source:  BioPlex,STRINGDB
ATG3
Tbio
Novelty:  0.00541077
p_int:  0.999954646
p_ni:  0.000042955
p_wrong:  0.000002398
Score:  0.995
Data Source:  BioPlex,STRINGDB
TBC1D25
Tbio
Novelty:  0.06756361
p_int:  0.999669652
p_ni:  0.000035326
p_wrong:  0.000295023
Score:  0.958
Data Source:  BioPlex,Reactome,STRINGDB
TGDS
Tbio
Family:  Enzyme
Novelty:  0.01813871
p_int:  0.997550658
p_ni:  0.001154403
p_wrong:  0.001294939
Score:  0.309
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.996985982
p_ni:  0.002688345
p_wrong:  0.000325673
Data Source:  BioPlex
FOXN4
Tbio
Family:  TF
Novelty:  0.04762528
p_int:  0.951195845
p_ni:  0.048117972
p_wrong:  0.000686183
Score:  0.379
Data Source:  BioPlex,STRINGDB
TSPAN3
Tbio
Novelty:  0.06362133
p_int:  0.756248278
p_ni:  0.00342104
p_wrong:  0.240330682
Data Source:  BioPlex
ATG7
Tchem
Novelty:  0.00120728
Score:  0.997
Data Source:  STRINGDB
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
Score:  0.997
Data Source:  STRINGDB
Nearest Tclin Targets (19)
Explore Nearest Tclin Targets
Pathways (29)
Autophagy (R-HSA-9612973)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autophagy
Reactome
Cellular responses to external stimuli
Reactome
Macroautophagy
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Autophagy
Cellular responses to external stimuli
Macroautophagy
Membrane Trafficking
Rab regulation of trafficking
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
4
7
6
15.8
99.5
apolipoprotein B measurement
2
5
6
97.6
low density lipoprotein cholesterol measurement
7
5
12
97.1
total cholesterol measurement
4
4
8
95.8
birth weight
4
3
4
89.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
alkaline phosphatase measurement
6
15.8
99.5
apolipoprotein B measurement
6
97.6
low density lipoprotein cholesterol measurement
12
97.1
total cholesterol measurement
8
95.8
birth weight
4
89.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GABA type A receptor-associated protein
VGNC:51661
748888
Macaque
GABA type A receptor-associated protein
714597
Mouse
MGI:1861742
56486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GABA type A receptor-associated protein
Macaque
GABA type A receptor-associated protein
Mouse
Publication Statistics
PubMed Score 233.56
PubMed score by year
PubTator Score 739.36
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title