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Tbio
GAB2
GRB2-associated-binding protein 2

Protein Summary
Description
Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340149
  • ENSP00000343959
  • ENSG00000033327
  • ENST00000361507
  • ENSP00000354952

Symbol
  • KIAA0571
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.96
kinase
0.92
transcription factor binding site profile
0.9
transcription factor
0.77
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.74   (req: < 5)
Gene RIFs: 88   (req: <= 3)
Antibodies: 654   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.74   (req: >= 5)
Gene RIFs: 88   (req: > 3)
Antibodies: 654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (154)
GRAP2
Tbio
Novelty:  0.00503901
p_int:  0.999999997
p_ni:  1e-9
p_wrong:  2e-9
Score:  0.898
Data Source:  BioPlex,STRINGDB
TGM4
Tbio
Family:  Enzyme
Novelty:  0.01478178
p_int:  0.999999992
p_ni:  7e-9
p_wrong:  1e-9
Score:  0.485
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999996293
p_ni:  0.000003693
p_wrong:  1.4e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PTPN11
Tchem
Family:  Enzyme
Novelty:  0.00073124
Score:  0.988
Data Source:  Reactome,STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.981
Data Source:  STRINGDB
LYN
Tclin
Family:  Kinase
Novelty:  0.00097393
Score:  0.981
Data Source:  Reactome,STRINGDB
MAPK1
Tchem
Family:  Kinase
Novelty:  0.00061058
Score:  0.973
Data Source:  STRINGDB
A1BG
Tbio
Novelty:  0.00508743
Score:  0.972
Data Source:  STRINGDB
FYN
Tclin
Family:  Kinase
Novelty:  0.00072167
Score:  0.971
Data Source:  Reactome,STRINGDB
SYK
Tclin
Family:  Kinase
Novelty:  0.00058994
Score:  0.97
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (76)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Cytokine Signaling in Immune system
Developmental Biology
Disease
Diseases of signal transduction
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (14)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
3
82.9
hair color
2
1
0
1.1
76.4
aspartate aminotransferase measurement
1
1
0
10
75.7
total cholesterol measurement
2
2
2
74
age at menarche
2
2
1
3.1
66.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
82.9
hair color
0
1.1
76.4
aspartate aminotransferase measurement
0
10
75.7
total cholesterol measurement
2
74
age at menarche
1
3.1
66.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated binding protein 2
VGNC:11785
748918
Macaque
GRB2 associated binding protein 2
700197
Mouse
MGI:1333854
14389
Rat
RGD:621367
84477
Horse
GRB2 associated binding protein 2
100062877
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GRB2 associated binding protein 2
Macaque
GRB2 associated binding protein 2
Mouse
Rat
Horse
GRB2 associated binding protein 2
Publication Statistics
PubMed Score 171.74
PubMed score by year
PubTator Score 118.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title