Tbio GAB2 GRB2-associated-binding protein 2

Protein Summary

Description

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. This gene is a member of the GRB2-associated binding protein (GAB) gene family. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Nov 2009]

Uniprot Accession IDs

• Q9UQC2
• A2RRM2
• A6NEW9
• A7MD36
• O60317

Gene Name

• GAB2

Ensembl ID

• ENST00000340149
• ENSP00000343959
• ENSG00000033327
• ENST00000361507
• ENSP00000354952

Symbol

• KIAA0571

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
kinase	0.92
transcription factor binding site profile	0.9
transcription factor	0.77
histone modification site profile	0.76

Protein Classes

PANTHER Classes

Protein / Transmembrane Receptor Regulatory/adaptor Protein / Grb2-associated-binding Protein 2

DTO Classes

Protein / Receptor / Grb2-associated-binding Protein 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.74   (req: < 5)

Gene RIFs: 88   (req: <= 3)

Antibodies: 654   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 171.74   (req: >= 5)

Gene RIFs: 88   (req: > 3)

Antibodies: 654   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (4)

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (154)

Explore Interacting Targets

1 – 10 of 154

• See Interactions on String-DB

GRAP2

Tbio

Novelty:  0.00503901

p_int:  0.999999997

p_ni:  1e-9

p_wrong:  2e-9

Score:  0.898

Data Source:  BioPlex,STRINGDB

TGM4

Tbio

Family:  Enzyme

Novelty:  0.01478178

p_int:  0.999999992

p_ni:  7e-9

p_wrong:  1e-9

Score:  0.485

Data Source:  BioPlex,STRINGDB

GRB2

Tchem

Novelty:  0.00091605

p_int:  0.999996293

p_ni:  0.000003693

p_wrong:  1.4e-8

Score:  0.999

Data Source:  BioPlex,Reactome,STRINGDB

PTPN11

Tchem

Family:  Enzyme

Novelty:  0.00073124

Score:  0.988

Data Source:  Reactome,STRINGDB

AKT1

Tchem

Family:  Kinase

Novelty:  0.00003185

Score:  0.981

Data Source:  STRINGDB

LYN

Tclin

Family:  Kinase

Novelty:  0.00097393

Score:  0.981

Data Source:  Reactome,STRINGDB

MAPK1

Tchem

Family:  Kinase

Novelty:  0.00061058

Score:  0.973

Data Source:  STRINGDB

A1BG

Tbio

Novelty:  0.00508743

Score:  0.972

Data Source:  STRINGDB

FYN

Tclin

Family:  Kinase

Novelty:  0.00072167

Score:  0.971

Data Source:  Reactome,STRINGDB

SYK

Tclin

Family:  Kinase

Novelty:  0.00058994

Score:  0.97

Data Source:  Reactome,STRINGDB

Nearest Tclin Targets (5)

Explore Nearest Tclin Targets

Upstream (3)

Downstream (2)

1 – 3 of 3

FYN

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  4

1: Fc epsilon RI signaling pathway

2: Sphingolipid signaling pathway

3: Phospholipase D signaling pathway

4: Osteoclast differentiation

LYN

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  2

1: Fc epsilon RI signaling pathway

2: Fc gamma R-mediated phagocytosis

HCK

Tclin

Family:  Kinase

KEGG Distance:  1

Common Pathways:  1

1: Fc gamma R-mediated phagocytosis

Pathways (76)

Reactome (32)

KEGG (7)

PathwayCommons (23)

WikiPathways (14)

Axon guidance (R-HSA-422475)

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5

1 – 5 of 32

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202

Name	Explore in Pharos	Explore in Source
Axon guidance	533 targets	R-HSA-422475
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Developmental Biology	1055 targets	R-HSA-1266738
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (14)

Functions (4)

Components (3)

Processes (7)

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1 – 4 of 4

GO Term	Evidence	Assigned by
transmembrane receptor protein tyrosine kinase adaptor activity	Inferred from Direct Assay (IDA)	UniProtKB
phosphatidylinositol-3,4,5-trisphosphate binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
phosphatidylinositol-3,4-bisphosphate binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
1-phosphatidylinositol-3-kinase activity	Traceable Author Statement (TAS)	Reactome

Disease Associations (null)

No disease associations found

GWAS Traits (21)

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5

1 – 5 of 21

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	3	2	3		82.9
hair color	EFO_0003924	2	1	0	1.1	76.4
aspartate aminotransferase measurement	EFO_0004736	1	1	0	10	75.7
total cholesterol measurement	EFO_0004574	2	2	2		74
age at menarche	EFO_0004703	2	2	1	3.1	66.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 21

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
glomerular filtration rate	EFO_0005208	3		82.9
hair color	EFO_0003924	0	1.1	76.4
aspartate aminotransferase measurement	EFO_0004736	0	10	75.7
total cholesterol measurement	EFO_0004574	2		74
age at menarche	EFO_0004703	1	3.1	66.6

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Alternative splicing
Cell membrane
Complete proteome
Cytoplasm
Membrane
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
age at menarche
Alzheimer's disease
aspartate aminotransferase measurement
body height
body mass index
creatine kinase measurement
creatinine measurement
diastolic blood pressure
glomerular filtration rate
hair color

MGI Phenotype Find Similar Targets

No Header	No Header
cellular phenotype
hematopoietic system phenotype
immune system phenotype
skeleton phenotype

IDG Resources

No IDG generated resources found

Orthologs (11)

1 – 5 of 11

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	GRB2 associated binding protein 2	VGNC:11785	748918
Macaque	GRB2 associated binding protein 2		700197
Mouse	growth factor receptor bound protein 2-associated protein 2	MGI:1333854	14389
Rat	GRB2-associated binding protein 2	RGD:621367	84477
Horse	GRB2 associated binding protein 2		100062877

Species	Name	OMA	EggNOG	Inparanoid
Chimp	GRB2 associated binding protein 2
Macaque	GRB2 associated binding protein 2
Mouse	growth factor receptor bound protein 2-associated protein 2
Rat	GRB2-associated binding protein 2
Horse	GRB2 associated binding protein 2

Publication Statistics

PubMed Score 171.74

PubMed score by year

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PubTator Score 118.77

PubTator score by year

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Related Publications

Text Mined References (123)

GeneRif Annotations (88)

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PMID	Year	Title