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Tbio
G0S2
G0/G1 switch protein 2

Protein Summary
Description
Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367029
  • ENSP00000355996
  • ENSG00000123689
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
0.93
histone modification site profile
0.81
small molecule perturbation
0.81
disease
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.69   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.69   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (51)
PNPLA2
Tchem
Family:  Enzyme
Novelty:  0.00149181
p_int:  0.999999539
p_ni:  4.61e-7
Score:  0.901
Data Source:  BioPlex,STRINGDB
USP16
Tbio
Family:  Enzyme
Novelty:  0.13211126
p_int:  0.999989277
p_ni:  0.00001071
p_wrong:  1.2e-8
Data Source:  BioPlex
RNF20
Tbio
Family:  Enzyme
Novelty:  0.01238827
p_int:  0.999620364
p_ni:  0.000379636
Data Source:  BioPlex
SUSD1
Tdark
Novelty:  0.54249826
p_int:  0.999609046
p_ni:  0.000354934
p_wrong:  0.00003602
Data Source:  BioPlex
ANKRD54
Tbio
Novelty:  0.03101679
p_int:  0.999293397
p_ni:  0.000093959
p_wrong:  0.000612644
Data Source:  BioPlex
OIP5
Tbio
Novelty:  0.02546471
p_int:  0.997858902
p_ni:  0.000420439
p_wrong:  0.001720659
Data Source:  BioPlex
SEC23IP
Tbio
Novelty:  0.0925721
p_int:  0.995110971
p_ni:  0.004889029
Data Source:  BioPlex
FERMT2
Tbio
Novelty:  0.01020276
p_int:  0.993077668
p_ni:  0.00670779
p_wrong:  0.000214542
Data Source:  BioPlex
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.952260499
p_ni:  0.0477323
p_wrong:  0.000007201
Data Source:  BioPlex
RNF40
Tbio
Family:  Enzyme
Novelty:  0.07038528
p_int:  0.919311701
p_ni:  0.080688298
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (9)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Reactome
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PPARA activates gene expression
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
72.6
mean corpuscular volume
1
1
1
66.3
erythrocyte count
1
1
1
38.2
red blood cell density measurement
1
1
1
30
Oral cleft
1
1
1
29
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
72.6
mean corpuscular volume
1
66.3
erythrocyte count
1
38.2
red blood cell density measurement
1
30
Oral cleft
1
29
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1316737
14373
Rat
RGD:1311675
289388
Horse
G0/G1 switch 2
VGNC:18176
100056475
Cow
G0/G1 switch 2
VGNC:29174
507436
Opossum
G0/G1 switch 2
100015830
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Horse
G0/G1 switch 2
Cow
G0/G1 switch 2
Opossum
G0/G1 switch 2
Publication Statistics
PubMed Score 53.69
PubMed score by year
PubTator Score 37.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title