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Tbio
FZR1
Fizzy-related protein homolog

Protein Summary
Description
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313639
  • ENSP00000321800
  • ENSG00000105325
  • ENST00000395095
  • ENSP00000378529
  • ENST00000441788
  • ENSP00000410369

Symbol
  • CDH1
  • FYR
  • FZR
  • KIAA1242
  • FZR
  • CDH1
  • FZR2
  • HCDH
  • HCDH1
  • CDC20C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
biological process
0.91
small molecule perturbation
0.77
transcription factor
0.76
interacting protein
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.52   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.52   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (469)
CCNA2
Tchem
Novelty:  0.00049887
p_int:  1
Score:  0.979
Data Source:  BioPlex,STRINGDB
CUEDC2
Tbio
Novelty:  0.07403123
p_int:  1
Score:  0.347
Data Source:  BioPlex,STRINGDB
RRM2
Tclin
Family:  Enzyme
Novelty:  0.00112948
p_int:  0.999999994
p_ni:  6e-9
Score:  0.836
Data Source:  BioPlex,STRINGDB
FBXO5
Tbio
Novelty:  0.01571484
p_int:  0.99999999
p_ni:  1e-8
Score:  0.987
Data Source:  BioPlex,Reactome,STRINGDB
USP37
Tbio
Family:  Enzyme
Novelty:  0.05398974
p_int:  0.999993944
p_ni:  4.46e-7
p_wrong:  0.000005609
Score:  0.423
Data Source:  BioPlex,STRINGDB
ANAPC16
Tdark
Family:  Enzyme
Novelty:  0.06353035
p_int:  0.999993689
p_ni:  0.000006311
Score:  0.991
Data Source:  BioPlex,STRINGDB
CDCA3
Tbio
Novelty:  0.05136899
p_int:  0.999991159
p_ni:  0.000008841
Score:  0.856
Data Source:  BioPlex,STRINGDB
PRR36
Tdark
Novelty:  0.46274399
p_int:  0.999989583
p_ni:  7.98e-7
p_wrong:  0.00000962
Score:  0.187
Data Source:  BioPlex,STRINGDB
HCCS
Tbio
Family:  Enzyme
Novelty:  0.0022585
p_int:  0.999854154
p_ni:  0.000145846
Data Source:  BioPlex
ANAPC2
Tbio
Family:  Enzyme
Novelty:  0.19812984
p_int:  0.99979932
p_ni:  0.000200679
p_wrong:  1e-9
Score:  0.999
Data Source:  BioPlex,STRINGDB
Pathways (32)
APC/C-mediated degradation of cell cycle proteins (R-HSA-174143)

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Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Autodegradation of Cdh1 by Cdh1:APC/C
Name
Explore in Pharos
Explore in Source
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Autodegradation of Cdh1 by Cdh1:APC/C
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
3
3
94.2
appendicular lean mass
1
2
2
70.7
platelet crit
1
1
1
67.2
body weight
2
2
2
65.6
platelet count
2
2
2
62.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
94.2
appendicular lean mass
2
70.7
platelet crit
1
67.2
body weight
2
65.6
platelet count
2
62.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fizzy and cell division cycle 20 related 1
VGNC:14744
468665
Macaque
fizzy and cell division cycle 20 related 1
721711
Mouse
MGI:1926790
56371
Rat
RGD:1308713
314642
Dog
fizzy and cell division cycle 20 related 1
VGNC:41036
485059
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fizzy and cell division cycle 20 related 1
Macaque
fizzy and cell division cycle 20 related 1
Mouse
Rat
Dog
fizzy and cell division cycle 20 related 1
Publication Statistics
PubMed Score 95.52
PubMed score by year
PubTator Score 13.02
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title