Protein Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces ...more
- ENST00000358755
- ENSP00000351605
- ENSG00000164930
- ENST00000522566
- ENSP00000429055
- ENST00000523739
- ENSP00000429528
- FZ6
- FZ-6
- HFZ6
- NDNC10
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.84 | ||
PubMedID | 0.83 | ||
protein domain | 0.73 | ||
ligand (protein) | 0.68 | ||
tissue sample | 0.64 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.47 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 317 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 82.47 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 317 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (129)
NKAIN1
Family: Enzyme
Novelty: 0.52190272
p_int: 0.999965288
p_ni: 0.000034559
p_wrong: 1.53e-7
Data Source: BioPlex
ZNRF4
Novelty: 0.16505328
p_int: 0.999938907
p_ni: 0.000061066
p_wrong: 2.6e-8
Data Source: BioPlex
GP9
Novelty: 0.00365769
p_int: 0.999888777
p_ni: 0.000104114
p_wrong: 0.000007109
Data Source: BioPlex
LRRC55
Family: IC
Novelty: 0.25121277
p_int: 0.998916588
p_ni: 0.000949704
p_wrong: 0.000133708
Data Source: BioPlex
SYNE4
Novelty: 0.0739848
p_int: 0.99745067
p_ni: 0.000074077
p_wrong: 0.002475254
Data Source: BioPlex
VNN2
Novelty: 0.02286648
p_int: 0.996916929
p_ni: 0.000136585
p_wrong: 0.002946486
Data Source: BioPlex
TMPRSS12
Family: Enzyme
Novelty: 0.38051198
p_int: 0.926249368
p_ni: 0.006699953
p_wrong: 0.067050679
Score: 0.189
Data Source: BioPlex,STRINGDB
GABRE
Family: IC
Novelty: 0.03814541
p_int: 0.878401519
p_ni: 0.002053628
p_wrong: 0.119544853
Score: 0.171
Data Source: BioPlex,STRINGDB
ADGRG5
Family: GPCR
Novelty: 0.26575982
p_int: 0.857865687
p_ni: 0.001067888
p_wrong: 0.141066425
Score: 0.274
Data Source: BioPlex,STRINGDB
RAMP1
Novelty: 0.00831253
p_int: 0.780645922
p_ni: 0.000650149
p_wrong: 0.218703929
Data Source: BioPlex
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (68)
Reactome (14)
KEGG (13)
PathwayCommons (31)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Disease | ||||
Reactome | Diseases of signal transduction | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Class B/2 (Secretin family receptors) | ||||
Disease | ||||
Diseases of signal transduction | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (4)
Components (6)
Processes (14)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
mathematical ability | 2 | 1 | 2 | 21.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
mathematical ability | 2 | 21.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 6 | VGNC:869 | 464327 | |||||
Macaque | frizzled class receptor 6 | 694625 | ||||||
Mouse | MGI:108474 | 14368 | ||||||
Rat | RGD:628816 | 282581 | ||||||
Dog | frizzled class receptor 6 | VGNC:41034 | 403610 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | frizzled class receptor 6 | |||||
Macaque | frizzled class receptor 6 | |||||
Mouse | ||||||
Rat | ||||||
Dog | frizzled class receptor 6 | |||||
Publication Statistics
PubMed Score 82.47
PubMed score by year
PubTator Score 41.15
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (38)
GeneRif Annotations (24)
Items per page:
0 of 0
PMID | Year | Title |
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