Tbio FZD6 Frizzled-6

Protein Summary

Description

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Together with FZD3, is involved in the neural tube closure and plays a role in the regulation of the establishment of planar cell polarity (PCP), particularly in the orientation of asymmetric bundles of stereocilia on the apical faces of a subset of auditory and vestibular sensory cells located in the inner ear (By similarity). This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• O60353
• B4DRN0
• Q6N0A5
• Q6P9C3
• Q8WXR9
• Fz-6

Gene Name

• FZD6

Ensembl ID

• ENST00000358755
• ENSP00000351605
• ENSG00000164930
• ENST00000522566
• ENSP00000429055
• ENST00000523739
• ENSP00000429528

Symbol

• FZ6
• FZ-6
• HFZ6
• NDNC10

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.84
PubMedID	0.83
protein domain	0.73
ligand (protein)	0.68
tissue sample	0.64

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Frizzled-6

Protein / Receptor / G-protein Coupled Receptor / Frizzled-6

Protein / ... / Protease Inhibitor / Frizzled-6

DTO Classes

Protein / G-protein Coupled Receptor / Class F Frizzled-type / Frizzled Receptor / Frizzled-6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.47   (req: < 5)

Gene RIFs: 24   (req: <= 3)

Antibodies: 317   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.47   (req: >= 5)

Gene RIFs: 24   (req: > 3)

Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (129)

Explore Interacting Targets

1 – 10 of 129

• See Interactions on String-DB

NKAIN1

Tdark

Family:  Enzyme

Novelty:  0.52190272

p_int:  0.999965288

p_ni:  0.000034559

p_wrong:  1.53e-7

Data Source:  BioPlex

ZNRF4

Tbio

Novelty:  0.16505328

p_int:  0.999938907

p_ni:  0.000061066

p_wrong:  2.6e-8

Data Source:  BioPlex

GP9

Tbio

Novelty:  0.00365769

p_int:  0.999888777

p_ni:  0.000104114

p_wrong:  0.000007109

Data Source:  BioPlex

LRRC55

Tbio

Family:  IC

Novelty:  0.25121277

p_int:  0.998916588

p_ni:  0.000949704

p_wrong:  0.000133708

Data Source:  BioPlex

SYNE4

Tbio

Novelty:  0.0739848

p_int:  0.99745067

p_ni:  0.000074077

p_wrong:  0.002475254

Data Source:  BioPlex

VNN2

Tbio

Novelty:  0.02286648

p_int:  0.996916929

p_ni:  0.000136585

p_wrong:  0.002946486

Data Source:  BioPlex

TMPRSS12

Tdark

Family:  Enzyme

Novelty:  0.38051198

p_int:  0.926249368

p_ni:  0.006699953

p_wrong:  0.067050679

Score:  0.189

Data Source:  BioPlex,STRINGDB

GABRE

Tclin

Family:  IC

Novelty:  0.03814541

p_int:  0.878401519

p_ni:  0.002053628

p_wrong:  0.119544853

Score:  0.171

Data Source:  BioPlex,STRINGDB

ADGRG5

Tdark

Family:  GPCR

Novelty:  0.26575982

p_int:  0.857865687

p_ni:  0.001067888

p_wrong:  0.141066425

Score:  0.274

Data Source:  BioPlex,STRINGDB

RAMP1

Tclin

Novelty:  0.00831253

p_int:  0.780645922

p_ni:  0.000650149

p_wrong:  0.218703929

Data Source:  BioPlex

Nearest Tclin Targets (9)

Explore Nearest Tclin Targets

Upstream (7)

Downstream (2)

1 – 5 of 7

MAP2K1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

EGFR

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: Cushing syndrome

3: Breast cancer

4: Hepatocellular carcinoma

more:  3 more common pathways

BRAF

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  7

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  3 more common pathways

RAF1

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  9

1: Gastric cancer

2: mTOR signaling pathway

3: Breast cancer

4: Signaling pathways regulating pluripotency of stem cells

more:  5 more common pathways

MAP2K2

Tclin

Family:  Kinase

KEGG Distance:  5

Common Pathways:  10

1: Gastric cancer

2: mTOR signaling pathway

3: Cushing syndrome

4: Breast cancer

more:  6 more common pathways

Pathways (68)

Reactome (14)

KEGG (13)

PathwayCommons (31)

WikiPathways (10)

Beta-catenin independent WNT signaling (R-HSA-3858494)

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Find Similar Targets

Items per page:

5

1 – 5 of 14

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Reactome	Ca2+ pathway	61 targets	R-HSA-4086398
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	Disease	1105 targets	R-HSA-1643685
Reactome	Diseases of signal transduction	387 targets	R-HSA-5663202

Name	Explore in Pharos	Explore in Source
Beta-catenin independent WNT signaling	146 targets	R-HSA-3858494
Ca2+ pathway	61 targets	R-HSA-4086398
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Disease	1105 targets	R-HSA-1643685
Diseases of signal transduction	387 targets	R-HSA-5663202

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (24)

Functions (4)

Components (6)

Processes (14)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
Wnt-activated receptor activity	Inferred from Direct Assay (IDA)	BHF-UCL
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
Wnt-protein binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
G protein-coupled receptor activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (1)

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5

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2	1	2		21.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mathematical ability	EFO_0004875	2		21.5

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell membrane
Complete proteome
Cytoplasmic vesicle
Developmental protein
Disease mutation
Disulfide bond
G-protein coupled receptor
Glycoprotein
Membrane

GWAS Trait Find Similar Targets

No Header	No Header
mathematical ability

MGI Phenotype Find Similar Targets

No Header	No Header
integument phenotype

IDG Resources

No IDG generated resources found

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 6	VGNC:869	464327
Macaque	frizzled class receptor 6		694625
Mouse	frizzled class receptor 6	MGI:108474	14368
Rat	frizzled class receptor 6	RGD:628816	282581
Dog	frizzled class receptor 6	VGNC:41034	403610

Species	Name	OMA	EggNOG	Inparanoid
Chimp	frizzled class receptor 6
Macaque	frizzled class receptor 6
Mouse	frizzled class receptor 6
Rat	frizzled class receptor 6
Dog	frizzled class receptor 6

Publication Statistics

PubMed Score 82.47

PubMed score by year

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PubTator Score 41.15

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Patents

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Related Publications

Text Mined References (38)

GeneRif Annotations (24)

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10

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PMID	Year	Title