Protein Summary
Receptor for Wnt proteins (PubMed:9054360, PubMed:10097073, PubMed:20530549). Can activate WNT2, WNT10B, WNT5A, but not WNT2B or WNT4 (in vitro); the in vivo situation may be different since not all of these are known to be coexpressed (By similarity). In neurons, activation of WNT7A promotes formation of synapses (PubMed:20530549). Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and inter ...more
- ENST00000295417
- ENSP00000354607
- ENSG00000163251
- C2orf31
- HFZ5
- C2orf31
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.99 | ||
co-expressed gene | 0.99 | ||
transcription factor perturbation | 0.94 | ||
transcription factor binding site profile | 0.89 | ||
PubMedID | 0.86 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.4 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 398 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 69.4 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 398 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 40
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (147)
GPR21
Family: GPCR
Novelty: 0.90865557
p_int: 0.832675874
p_ni: 0.000003712
p_wrong: 0.167320414
Score: 0.2
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (75)
Reactome (17)
KEGG (13)
PathwayCommons (34)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Class B/2 (Secretin family receptors) | ||||
Disassembly of the destruction complex and recruitment of AXIN to the membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (52)
Functions (8)
Components (12)
Processes (32)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | FlyBase | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | ARUK-UCL | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 1 | 1 | 37 | |||||
hematocrit | 2 | 1 | 2 | 29.8 | |||||
glycine measurement | 1 | 1 | 1 | 29 | |||||
educational attainment | 1 | 1 | 1 | 27.1 | |||||
testosterone measurement | 1 | 1 | 1 | 22.8 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
hemoglobin measurement | 1 | 37 | |||||
hematocrit | 2 | 29.8 | |||||
glycine measurement | 1 | 29 | |||||
educational attainment | 1 | 27.1 | |||||
testosterone measurement | 1 | 22.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 5 | VGNC:10809 | 470627 | |||||
Mouse | MGI:108571 | 14367 | ||||||
Rat | RGD:631406 | 317674 | ||||||
Dog | frizzled class receptor 5 | VGNC:41033 | 100855544 | |||||
Cow | frizzled class receptor 5 | VGNC:29169 | 538536 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 5 | |||||
Mouse | ||||||
Rat | ||||||
Dog | frizzled class receptor 5 | |||||
Cow | frizzled class receptor 5 | |||||
Publication Statistics
PubMed Score 69.40
PubMed score by year
PubTator Score 41.70
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (49)
GeneRif Annotations (22)
Items per page:
0 of 0
PMID | Year | Title |
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