Protein Summary
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Requi ...more
- ENST00000240093
- ENSP00000240093
- ENSG00000104290
- ENST00000537916
- ENSP00000437489
- Fz-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 0.88 | ||
PubMedID | 0.78 | ||
protein domain | 0.73 | ||
pathway | 0.68 | ||
biological process | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 100.62 (req: < 5)
Gene RIFs: 22 (req: <= 3)
Antibodies: 420 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 100.62 (req: >= 5)
Gene RIFs: 22 (req: > 3)
Antibodies: 420 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
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Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (129)
VNN2
Novelty: 0.02286648
p_int: 0.999883026
p_ni: 0.000116955
p_wrong: 1.9e-8
Data Source: BioPlex
XAGE1A
Novelty: 0.04421526
p_int: 0.999789754
p_ni: 0.000210203
p_wrong: 4.4e-8
Data Source: BioPlex
UPK1A
Novelty: 0.01748122
p_int: 0.999788027
p_ni: 0.000055802
p_wrong: 0.000156171
Data Source: BioPlex
GPR21
Family: GPCR
Novelty: 0.90865557
p_int: 0.999513608
p_ni: 0.000398671
p_wrong: 0.000087721
Data Source: BioPlex
SYNE4
Novelty: 0.0739848
p_int: 0.999377269
p_ni: 0.000353119
p_wrong: 0.000269612
Score: 0.198
Data Source: BioPlex,STRINGDB
ADGRG5
Family: GPCR
Novelty: 0.26575982
p_int: 0.999086792
p_ni: 0.000906767
p_wrong: 0.000006442
Data Source: BioPlex
ZBBX
Novelty: 1.66474399
p_int: 0.874832977
p_ni: 0.012378008
p_wrong: 0.112789015
Score: 0.215
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (9)
Upstream (7)
Downstream (2)
1 – 5 of 7
Pathways (64)
Reactome (9)
KEGG (15)
PathwayCommons (30)
WikiPathways (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asymmetric localization of PCP proteins | ||||
Reactome | Beta-catenin independent WNT signaling | ||||
Reactome | Ca2+ pathway | ||||
Reactome | Class B/2 (Secretin family receptors) | ||||
Reactome | GPCR ligand binding | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asymmetric localization of PCP proteins | ||||
Beta-catenin independent WNT signaling | ||||
Ca2+ pathway | ||||
Class B/2 (Secretin family receptors) | ||||
GPCR ligand binding | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (4)
Components (11)
Processes (23)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (0)
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | frizzled class receptor 3 | VGNC:868 | 472726 | |||||
Macaque | frizzled class receptor 3 | 713839 | ||||||
Mouse | MGI:108476 | 14365 | ||||||
Rat | RGD:628814 | 266715 | ||||||
Dog | frizzled class receptor 3 | VGNC:41031 | 486093 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | frizzled class receptor 3 | |||||
Macaque | frizzled class receptor 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | frizzled class receptor 3 | |||||
Publication Statistics
PubMed Score 100.62
PubMed score by year
PubTator Score 45.70
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (41)
GeneRif Annotations (22)
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