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Tbio
FZD3
Frizzled-3

Protein Summary
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by Wnt5A stimulates PKC activity via a G-protein-dependent mechanism. Involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Plays a role in controlling early axon growth and guidance processes necessary for the formation of a subset of central and peripheral major fiber tracts. Requi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240093
  • ENSP00000240093
  • ENSG00000104290
  • ENST00000537916
  • ENSP00000437489

Symbol
  • Fz-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
PubMedID
0.78
protein domain
0.73
pathway
0.68
biological process
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.62   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 420   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.62   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 420   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (129)
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.999883026
p_ni:  0.000116955
p_wrong:  1.9e-8
Data Source:  BioPlex
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.999789754
p_ni:  0.000210203
p_wrong:  4.4e-8
Data Source:  BioPlex
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.999788027
p_ni:  0.000055802
p_wrong:  0.000156171
Data Source:  BioPlex
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.999513608
p_ni:  0.000398671
p_wrong:  0.000087721
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.999377269
p_ni:  0.000353119
p_wrong:  0.000269612
Score:  0.198
Data Source:  BioPlex,STRINGDB
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.999086792
p_ni:  0.000906767
p_wrong:  0.000006442
Data Source:  BioPlex
ZBBX
Tdark
Novelty:  1.66474399
p_int:  0.874832977
p_ni:  0.012378008
p_wrong:  0.112789015
Score:  0.215
Data Source:  BioPlex,STRINGDB
VANGL2
Tbio
Novelty:  0.00529796
Score:  0.989
Data Source:  Reactome,STRINGDB
WNT5A
Tbio
Novelty:  0.00125563
Score:  0.985
Data Source:  STRINGDB
DVL2
Tbio
Novelty:  0.00833084
Score:  0.984
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
RAF1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  11
more:  7 more common pathways
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  11
more:  7 more common pathways
BRAF
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  11
more:  7 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  8
more:  4 more common pathways
Pathways (64)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Ca2+ pathway
Class B/2 (Secretin family receptors)
GPCR ligand binding
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 3
VGNC:868
472726
Macaque
frizzled class receptor 3
713839
Mouse
MGI:108476
14365
Rat
RGD:628814
266715
Dog
frizzled class receptor 3
VGNC:41031
486093
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 3
Macaque
frizzled class receptor 3
Mouse
Rat
Dog
frizzled class receptor 3
Publication Statistics
PubMed Score 100.62
PubMed score by year
PubTator Score 45.70
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title