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Tchem
FZD2
Frizzled-2

Protein Summary
Description
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene enc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315323
  • ENSP00000323901
  • ENSG00000180340

Symbol
  • Fz2
  • fz-2
  • fzE2
  • hFz2
  • OMOD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.97
transcription factor perturbation
0.84
histone modification site profile
0.81
biological process
0.78
transcription factor binding site profile
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.67   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 159.67   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (161)
UPK1A
Tbio
Novelty:  0.01748122
p_int:  0.999777299
p_ni:  0.000199697
p_wrong:  0.000023004
Data Source:  BioPlex
MPPE1
Tbio
Family:  Enzyme
Novelty:  0.16027847
p_int:  0.998945463
p_ni:  0.001054537
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.998124028
p_ni:  0.001864049
p_wrong:  0.000011923
Data Source:  BioPlex
PTGIR
Tclin
Family:  GPCR
Novelty:  0.0091906
p_int:  0.998081501
p_ni:  0.001906689
p_wrong:  0.00001181
Data Source:  BioPlex
TMPRSS11B
Tdark
Family:  Enzyme
Novelty:  1.20690443
p_int:  0.997583968
p_ni:  0.002407298
p_wrong:  0.000008734
Data Source:  BioPlex
LAMP1
Tbio
Novelty:  0.00067563
p_int:  0.997485575
p_ni:  0.002514425
Score:  0.22
Data Source:  BioPlex,STRINGDB
GPR21
Tdark
Family:  GPCR
Novelty:  0.90865557
p_int:  0.996367898
p_ni:  0.002642975
p_wrong:  0.000989127
Data Source:  BioPlex
RAMP1
Tclin
Novelty:  0.00831253
p_int:  0.994816033
p_ni:  0.005179518
p_wrong:  0.00000445
Data Source:  BioPlex
NRN1
Tbio
Novelty:  0.01198116
p_int:  0.993222986
p_ni:  0.006315891
p_wrong:  0.000461124
Data Source:  BioPlex
LYPD6
Tbio
Novelty:  0.13867181
p_int:  0.980140723
p_ni:  0.019471529
p_wrong:  0.000387748
Score:  0.213
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
BRAF
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
EGFR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
Pathways (67)
Asymmetric localization of PCP proteins (R-HSA-4608870)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asymmetric localization of PCP proteins
Reactome
Beta-catenin independent WNT signaling
Reactome
Ca2+ pathway
Reactome
Class B/2 (Secretin family receptors)
Reactome
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Name
Explore in Pharos
Explore in Source
Asymmetric localization of PCP proteins
Beta-catenin independent WNT signaling
Ca2+ pathway
Class B/2 (Secretin family receptors)
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
2
3
73.6
educational attainment
1
2
2
33.4
pulse pressure measurement
1
1
1
28.9
platelet crit
2
1
2
15
hip bone size
1
1
1
7.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
73.6
educational attainment
2
33.4
pulse pressure measurement
1
28.9
platelet crit
2
15
hip bone size
1
7.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 2
VGNC:12141
454731
Macaque
frizzled class receptor 2
712381
Mouse
MGI:1888513
57265
Rat
RGD:71012
64512
Dog
frizzled class receptor 2
VGNC:41030
490937
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 2
Macaque
frizzled class receptor 2
Mouse
Rat
Dog
frizzled class receptor 2
Publication Statistics
PubMed Score 159.67
PubMed score by year
PubTator Score 52.17
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title