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Tbio
FZD10
Frizzled-10

Protein Summary
Description
Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of sig ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229030
  • ENSP00000229030
  • ENSG00000111432

Symbol
  • Fz10
  • FzE7
  • CD350
  • FZ-10
  • hFz10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.79
biological process
0.76
protein domain
0.73
tissue sample
0.67
interacting protein
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.69   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.69   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (112)
EVI5
Tbio
Novelty:  0.05021983
p_int:  0.999998298
p_ni:  4.52e-7
p_wrong:  0.00000125
Score:  0.189
Data Source:  BioPlex,STRINGDB
TMED8
Tdark
Novelty:  1.41977071
p_int:  0.999951137
p_ni:  0.000048857
p_wrong:  6e-9
Data Source:  BioPlex
GSTCD
Tbio
Family:  Enzyme
Novelty:  0.11613228
p_int:  0.999902658
p_ni:  0.000059762
p_wrong:  0.00003758
Score:  0.202
Data Source:  BioPlex,STRINGDB
VPS8
Tbio
Novelty:  0.05178496
p_int:  0.999484807
p_ni:  0.000515152
p_wrong:  4e-8
Data Source:  BioPlex
ATRIP
Tbio
Novelty:  0.01415267
p_int:  0.999479821
p_ni:  0.000520177
p_wrong:  3e-9
Data Source:  BioPlex
EVI5L
Tbio
Novelty:  0.70769557
p_int:  0.997249611
p_ni:  0.00267351
p_wrong:  0.00007688
Data Source:  BioPlex
VEZT
Tbio
Novelty:  0.06274137
p_int:  0.994386569
p_ni:  0.00555189
p_wrong:  0.000061541
Data Source:  BioPlex
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.990265726
p_ni:  0.009734274
Data Source:  BioPlex
NCAPD2
Tbio
Novelty:  0.04960987
p_int:  0.988909101
p_ni:  0.011090736
p_wrong:  1.63e-7
Data Source:  BioPlex
XPO7
Tbio
Novelty:  0.05412704
p_int:  0.987786775
p_ni:  0.012213225
Data Source:  BioPlex
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 5 of 7
EGFR
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
BRAF
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  7
more:  3 more common pathways
MAP2K2
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
MAP2K1
Tclin
Family:  Kinase
KEGG Distance:  5
Common Pathways:  10
more:  6 more common pathways
Pathways (54)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
GPCR ligand binding
Signal Transduction
Signaling by GPCR
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
2
54.3
balding measurement
2
1
2
40.6
mathematical ability
3
1
3
13.6
2
1
1
1.2
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
54.3
balding measurement
2
40.6
mathematical ability
3
13.6
1
1.2
12.2
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 10
VGNC:5395
467160
Macaque
frizzled class receptor 10
717812
Mouse
MGI:2136761
93897
Dog
frizzled class receptor 10
VGNC:41029
486232
Horse
frizzled class receptor 10
VGNC:18170
100062909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
frizzled class receptor 10
Macaque
frizzled class receptor 10
Mouse
Dog
frizzled class receptor 10
Horse
frizzled class receptor 10
Publication Statistics
PubMed Score 42.69
PubMed score by year
PubTator Score 20.00
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title