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Tclin
FYN
Tyrosine-protein kinase Fyn

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229471
  • ENSP00000229471
  • ENSG00000010810
  • ENST00000354650
  • ENSP00000346671
  • ENST00000368667
  • ENSP00000357656
  • ENST00000368678
  • ENSP00000357667
  • ENST00000368682
  • ENSP00000357671
  • ENST00000538466
  • ENSP00000440646

Symbol
  • SLK
  • SYN
  • p59-FYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
virus
1
viral protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1307.1   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 933   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1307.1   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (585)
RPS6KA1
Tchem
Family:  Kinase
Novelty:  0.00178073
p_int:  0.999995634
p_ni:  0.000004366
Score:  0.3
Data Source:  BioPlex,STRINGDB
SRC
Tclin
Family:  Kinase
Novelty:  0.00008479
p_int:  0.999993256
p_ni:  0.00000671
p_wrong:  3.4e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
HSP90AB3P
Tdark
p_int:  0.999989451
p_ni:  0.000010549
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.999985308
p_ni:  0.000014662
p_wrong:  3e-8
Data Source:  BioPlex
RPS6KA3
Tchem
Family:  Kinase
Novelty:  0.00221219
p_int:  0.999979116
p_ni:  0.000020884
Score:  0.371
Data Source:  BioPlex,STRINGDB
RPS6KA2
Tchem
Family:  Kinase
Novelty:  0.00409407
p_int:  0.999930595
p_ni:  0.000069404
Score:  0.212
Data Source:  BioPlex,STRINGDB
YES1
Tclin
Family:  Kinase
Novelty:  0.00534936
p_int:  0.999890557
p_ni:  0.000109443
Score:  0.999
Data Source:  BioPlex,STRINGDB
PRUNE2
Tbio
Novelty:  0.05701865
p_int:  0.999872437
p_ni:  0.000127563
Score:  0.818
Data Source:  BioPlex,STRINGDB
HSP90AB4P
Tdark
p_int:  0.999790771
p_ni:  0.000209228
Data Source:  BioPlex
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.995916269
p_ni:  0.004083729
p_wrong:  1e-9
Score:  0.207
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (165)
Activated NTRK2 signals through FYN (R-HSA-9032500)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 75
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NTRK2 signals through FYN
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Axon guidance
Reactome
C-type lectin receptors (CLRs)
Name
Explore in Pharos
Explore in Source
Activated NTRK2 signals through FYN
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Axon guidance
C-type lectin receptors (CLRs)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (101)
Find Similar Targets
Items per page:
10
1 – 10 of 21
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ARUK-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.5
92.4
balding measurement
1
2
2
88.8
3
2
0
1.9
85
psoriasis vulgaris
1
1
0
1.4
75.9
intraocular pressure measurement
1
2
2
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.5
92.4
balding measurement
2
88.8
0
1.9
85
psoriasis vulgaris
0
1.4
75.9
intraocular pressure measurement
2
66.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FYN proto-oncogene, Src family tyrosine kinase
VGNC:9963
462944
Macaque
FYN proto-oncogene, Src family tyrosine kinase
574214
Mouse
MGI:95602
14360
Rat
RGD:2641
25150
Dog
FYN proto-oncogene, Src family tyrosine kinase
VGNC:41027
475032
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FYN proto-oncogene, Src family tyrosine kinase
Macaque
FYN proto-oncogene, Src family tyrosine kinase
Mouse
Rat
Dog
FYN proto-oncogene, Src family tyrosine kinase
Publication Statistics
PubMed Score 1307.10
PubMed score by year
PubTator Score 750.31
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title