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Tbio
FYCO1
FYVE and coiled-coil domain-containing protein 1

Protein Summary
Description
May mediate microtubule plus end-directed vesicle transport. This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296137
  • ENSP00000296137
  • ENSG00000163820
  • ENST00000535325
  • ENSP00000441178

Symbol
  • ZFYVE7
  • CATC2
  • RUFY3
  • ZFYVE7
  • CTRCT18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.83
microRNA
0.81
interacting protein
0.79
cell line
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.96   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.96   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
FAM9C
Tdark
Novelty:  0.86727989
p_int:  0.999999956
p_ni:  4.4e-8
Data Source:  BioPlex
TRUB2
Tdark
Family:  Enzyme
Novelty:  0.4130414
p_int:  0.999999887
p_ni:  1.13e-7
Data Source:  BioPlex
DTNB
Tbio
Novelty:  0.0586565
p_int:  0.999999696
p_ni:  3.04e-7
Data Source:  BioPlex
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999999578
p_ni:  4.22e-7
Score:  0.158
Data Source:  BioPlex,STRINGDB
CADPS
Tbio
Novelty:  0.01737775
p_int:  0.999998685
p_ni:  0.000001315
Data Source:  BioPlex
CCDC68
Tbio
Novelty:  0.1262502
p_int:  0.999998581
p_ni:  0.000001419
Score:  0.161
Data Source:  BioPlex,STRINGDB
MLYCD
Tchem
Family:  Enzyme
Novelty:  0.01670441
p_int:  0.999987173
p_ni:  0.000012825
p_wrong:  2e-9
Score:  0.237
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999810048
p_ni:  0.000189952
Data Source:  BioPlex
SGF29
Tbio
Family:  Epigenetic
Novelty:  0.0426456
p_int:  0.999720598
p_ni:  0.000279402
Data Source:  BioPlex
SASS6
Tbio
Novelty:  0.00680548
p_int:  0.999682012
p_ni:  0.000317072
p_wrong:  9.16e-7
Score:  0.745
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
9
6
5
1.8
99.7
respiratory symptom measurement
2
3
4
94
Oral ulcer
1
2
0
1.1
85.8
CCL2 measurement
2
2
2
78.6
macrophage inflammatory protein 1b measurement
1
1
1
76.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
COVID-19
5
1.8
99.7
respiratory symptom measurement
4
94
Oral ulcer
0
1.1
85.8
CCL2 measurement
2
78.6
macrophage inflammatory protein 1b measurement
1
76.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FYVE and coiled-coil domain containing 1
VGNC:11398
100614690
Macaque
FYVE and coiled-coil domain containing 1
713756
Mouse
MGI:107277
17281
Rat
RGD:1309069
301085
Dog
FYVE and coiled-coil domain containing 1
VGNC:41026
476649
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FYVE and coiled-coil domain containing 1
Macaque
FYVE and coiled-coil domain containing 1
Mouse
Rat
Dog
FYVE and coiled-coil domain containing 1
Publication Statistics
PubMed Score 27.96
PubMed score by year
PubTator Score 8.72
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title