Tbio FYCO1 FYVE and coiled-coil domain-containing protein 1

Protein Summary

Description

May mediate microtubule plus end-directed vesicle transport. This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011]

Uniprot Accession IDs

• Q9BQS8
• B7ZKT7
• Q3MJE6
• Q86T41
• Q86TB1
• Q8TEF9
• Q96IV5
• Q9H8P9

Gene Name

• FYCO1

Ensembl ID

• ENST00000296137
• ENSP00000296137
• ENSG00000163820
• ENST00000535325
• ENSP00000441178

Symbol

• ZFYVE7
• CATC2
• RUFY3
• ZFYVE7
• CTRCT18

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
virus perturbation	0.83
microRNA	0.81
interacting protein	0.79
cell line	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.96   (req: < 5)

Gene RIFs: 17   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.96   (req: >= 5)

Gene RIFs: 17   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0