Tbio FYB2 FYN-binding protein 2

Protein Summary

Description

Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501).

Uniprot Accession IDs

• Q5VWT5
• Q63HM3
• Q6ZUY6

Gene Name

• FYB2

Ensembl ID

• ENST00000343433
• ENSP00000345972
• ENSG00000187889

Symbol

• ARAP
• C1orf168
• ARAP
• C1orf168

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 49   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Expression Data (0 Tissues)

tutorial

No expression data found

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Related Tools (2)

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (31)

Explore Interacting Targets

1 – 10 of 31

• See Interactions on String-DB

ZC3H11A

Tbio

Novelty:  0.49683634

Score:  0.663

Data Source:  STRINGDB

SIPA1L2

Tbio

Novelty:  0.2002618

Score:  0.618

Data Source:  STRINGDB

DNAH7

Tbio

Novelty:  0.13519686

Score:  0.578

Data Source:  STRINGDB

RALGAPA2

Tdark

Family:  Enzyme

Novelty:  0.12467725

Score:  0.578

Data Source:  STRINGDB

DNAH1

Tbio

Novelty:  0.0369386

Score:  0.578

Data Source:  STRINGDB

MYO7B

Tbio

Novelty:  0.10660261

Score:  0.567

Data Source:  STRINGDB

CDH24

Tbio

Novelty:  0.41415899

Score:  0.557

Data Source:  STRINGDB

DNAJC13

Tbio

Novelty:  0.03251995

Score:  0.546

Data Source:  STRINGDB

FRAS1

Tbio

Novelty:  0.02114063

Score:  0.542

Data Source:  STRINGDB

LIMCH1

Tbio

Novelty:  0.13191572

Score:  0.537

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (7)

Components (3)

Processes (4)

Find Similar Targets

Items per page:

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1 – 3 of 3

GO Term	Evidence	Assigned by
immunological synapse	Inferred from Direct Assay (IDA)	UniProtKB
membrane raft	Inferred from Direct Assay (IDA)	UniProtKB
plasma membrane	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations (null)

No disease associations found

GWAS Traits (0)

No GWAS traits found

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Complete proteome
Membrane
Phosphoprotein
Polymorphism
Reference proteome
SH3 domain

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	FYN binding protein 2	VGNC:4986	456885
Macaque	FYN binding protein 2		716080
Mouse	FYN binding protein 2	MGI:2685466	242594
Rat	-
Dog	FYN binding protein 2	VGNC:41025	610368

Species	Name	OMA	EggNOG	Inparanoid
Chimp	FYN binding protein 2
Macaque	FYN binding protein 2
Mouse	FYN binding protein 2
Rat	-
Dog	FYN binding protein 2

Publication Statistics

PubMed Score 0.65

PubMed score by year

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Related Publications

Text Mined References (7)

GeneRif Annotations (1)

Items per page:

10

0 of 0

PMID	Year	Title