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Tbio
FYB2
FYN-binding protein 2

Protein Summary
Description
Adapter protein that plays a role in T-cell receptor (TCR)-mediated activation of signaling pathways. Required for T-cell activation and integrin-mediated T-cell adhesion in response to TCR stimulation (PubMed:27335501).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343433
  • ENSP00000345972
  • ENSG00000187889

Symbol
  • ARAP
  • C1orf168
  • ARAP
  • C1orf168
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 49   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.65   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 49   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (2)
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
ZC3H11A
Tbio
Novelty:  0.49683634
Score:  0.663
Data Source:  STRINGDB
SIPA1L2
Tbio
Novelty:  0.2002618
Score:  0.618
Data Source:  STRINGDB
DNAH7
Tbio
Novelty:  0.13519686
Score:  0.578
Data Source:  STRINGDB
RALGAPA2
Tdark
Family:  Enzyme
Novelty:  0.12467725
Score:  0.578
Data Source:  STRINGDB
DNAH1
Tbio
Novelty:  0.0369386
Score:  0.578
Data Source:  STRINGDB
MYO7B
Tbio
Novelty:  0.10660261
Score:  0.567
Data Source:  STRINGDB
CDH24
Tbio
Novelty:  0.41415899
Score:  0.557
Data Source:  STRINGDB
DNAJC13
Tbio
Novelty:  0.03251995
Score:  0.546
Data Source:  STRINGDB
FRAS1
Tbio
Novelty:  0.02114063
Score:  0.542
Data Source:  STRINGDB
LIMCH1
Tbio
Novelty:  0.13191572
Score:  0.537
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FYN binding protein 2
VGNC:4986
456885
Macaque
FYN binding protein 2
716080
Mouse
MGI:2685466
242594
Rat
Dog
FYN binding protein 2
VGNC:41025
610368
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FYN binding protein 2
Macaque
FYN binding protein 2
Mouse
Rat
Dog
FYN binding protein 2
Publication Statistics
PubMed Score 0.65
PubMed score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title