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Tbio
FXYD7
FXYD domain-containing ion transport regulator 7

Protein Summary
Description
This reference sequence was derived from multiple replicate ESTs and validated by similar human genomic sequence. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. This gene product, FXYD7, is novel and has not been characterized as a protein. [RefSeq curation by Kathleen J. Sweadner, Ph ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270310
  • ENSP00000270310
  • ENSG00000221946
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.63
gene perturbation
0.6
molecular function
0.6
PubMedID
0.57
tissue sample
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.12   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 171   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.12   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 171   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (21)
ATP1B1
Tclin
Family:  Transporter
Novelty:  0.025056
Score:  0.983
Data Source:  STRINGDB
ATP1A1
Tclin
Family:  Transporter
Novelty:  0.01078788
Score:  0.942
Data Source:  STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.937
Data Source:  STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
Score:  0.927
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.922
Data Source:  STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
Score:  0.92
Data Source:  STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
Score:  0.906
Data Source:  STRINGDB
FXYD4
Tdark
Family:  IC
Novelty:  0.11545177
Score:  0.831
Data Source:  STRINGDB
FXYD5
Tbio
Family:  IC
Novelty:  0.01598365
Score:  0.719
Data Source:  STRINGDB
FXYD3
Tbio
Family:  IC
Novelty:  0.01217832
Score:  0.705
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
6
8
99.2
calcium measurement
1
4
4
97.1
blood protein measurement
2
4
4
96.9
sex hormone-binding globulin measurement
6
2
6
94.7
mean platelet volume
3
3
3
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
8
99.2
calcium measurement
4
97.1
blood protein measurement
4
96.9
sex hormone-binding globulin measurement
6
94.7
mean platelet volume
3
93.3
Find similar targets by:
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1889006
57780
Rat
RGD:620830
63848
Cow
FXYD domain containing ion transport regulator 7
VGNC:29159
616128
Opossum
FXYD domain containing ion transport regulator 7 [Source:HGNC Symbol;Acc:HGNC:4034]
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
FXYD domain containing ion transport regulator 7
Opossum
FXYD domain containing ion transport regulator 7 [Source:HGNC Symbol;Acc:HGNC:4034]
Publication Statistics
PubMed Score 10.12
PubMed score by year
PubTator Score 3.07
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title