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Tbio
FXYD5
FXYD domain-containing ion transport regulator 5

Protein Summary
Description
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis. This gene encodes a member of a family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The approved human gene nomenclature for the family is FXYD-domain containing ion transport regulator. Mouse FXYD5 has been termed RIC (Related to Ion Channel). FXYD2, also known as the gamma subunit of the Na,K-ATPase, regulates the properties of that enzyme. FXYD1 (phospholemman), FXYD2 (gamma), FXYD3 (MAT-8), FXYD4 (CHIF), and FXYD5 (RIC) have been shown to induce channel activity in experimental expression systems. Transmembrane topology has been established for two family members (FXYD1 and FXYD2), with the N-terminus extracellular and the C-terminus on the cytoplasmic side of the membrane. This gene product, FXYD5, is a glycoprotein that functions in the up-regulati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342879
  • ENSP00000344254
  • ENSG00000089327
  • ENST00000392217
  • ENSP00000376051
  • ENST00000392219
  • ENSP00000376053
  • ENST00000423817
  • ENSP00000393848
  • ENST00000541435
  • ENSP00000443390
  • ENST00000590686
  • ENSP00000465667

Symbol
  • DYSAD
  • IWU1
  • RIC
  • IWU1
  • KCT1
  • OIT2
  • DYSAD
  • HSPC113
  • PRO6241
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.88
transcription factor perturbation
0.88
kinase perturbation
0.81
histone modification site profile
0.76
tissue sample
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.11   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 198   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 91.11   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 198   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
FXYD6
Tbio
Family:  IC
Novelty:  0.0503209
Score:  0.78
Data Source:  STRINGDB
FXYD3
Tbio
Family:  IC
Novelty:  0.01217832
Score:  0.728
Data Source:  STRINGDB
ARHGAP32
Tbio
Family:  Enzyme
Novelty:  0.03724426
Score:  0.726
Data Source:  STRINGDB
FXYD7
Tbio
Family:  IC
Novelty:  0.08820333
Score:  0.719
Data Source:  STRINGDB
FXYD4
Tdark
Family:  IC
Novelty:  0.11545177
Score:  0.708
Data Source:  STRINGDB
FXYD1
Tbio
Family:  IC
Novelty:  0.00421639
Score:  0.673
Data Source:  STRINGDB
CDH1
Tbio
Novelty:  0.00010629
Score:  0.67
Data Source:  STRINGDB
RIT1
Tbio
Family:  Enzyme
Novelty:  0.02780594
Score:  0.64
Data Source:  STRINGDB
ITGA7
Tbio
Novelty:  0.01243073
Score:  0.635
Data Source:  STRINGDB
FXYD2
Tclin
Family:  Enzyme
Novelty:  0.0196518
Score:  0.63
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (23)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
6
7
11
98.8
calcium measurement
3
5
6
94.7
triglyceride measurement
5
4
6
93.2
sex hormone-binding globulin measurement
9
2
8
10.8
92.9
reticulocyte count
7
3
7
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
11
98.8
calcium measurement
6
94.7
triglyceride measurement
6
93.2
sex hormone-binding globulin measurement
8
10.8
92.9
reticulocyte count
7
91.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 5
VGNC:3633
744650
Macaque
FXYD domain containing ion transport regulator 5
718467
Mouse
MGI:1201785
18301
Rat
RGD:620827
60338
Dog
FXYD domain containing ion transport regulator 5
VGNC:41023
612666
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 5
Macaque
FXYD domain containing ion transport regulator 5
Mouse
Rat
Dog
FXYD domain containing ion transport regulator 5
Publication Statistics
PubMed Score 91.11
PubMed score by year
PubTator Score 68.47
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title