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Tbio
FXYD3
FXYD domain-containing ion transport regulator 3

Protein Summary
Description
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). Isoform 1: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344013
  • ENSP00000339499
  • ENSG00000089356
  • ENST00000346446
  • ENSP00000328259
  • ENST00000435734
  • ENSP00000389770
  • ENST00000603181
  • ENSP00000474851
  • ENST00000603449
  • ENSP00000474055
  • ENST00000604255
  • ENSP00000473929
  • ENST00000604404
  • ENSP00000474438
  • ENST00000604621
  • ENSP00000474526
  • ENST00000605552
  • ENSP00000474855
  • ENST00000605677
  • ENSP00000474622

Symbol
  • MAT8
  • PLML
  • MAT8
  • PLML
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
transcription factor perturbation
0.8
virus perturbation
0.79
molecular function
0.76
phenotype
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.92   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.92   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0