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Tbio
FXYD3
FXYD domain-containing ion transport regulator 3

Protein Summary
Description
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which transports Na(+) out of the cell and K(+) into the cell (PubMed:17077088). Reduces glutathionylation of the NKA beta-1 subunit ATP1B1, thus reversing glutathionylation-mediated inhibition of ATP1B1 (PubMed:21454534). Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes (PubMed:7836447). Isoform 1: Decreases the apparent K+ and Na+ affinity of the sodium/potassium-transporting ATPase over a large range of membrane potentials. Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials. This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344013
  • ENSP00000339499
  • ENSG00000089356
  • ENST00000346446
  • ENSP00000328259
  • ENST00000435734
  • ENSP00000389770
  • ENST00000603181
  • ENSP00000474851
  • ENST00000603449
  • ENSP00000474055
  • ENST00000604255
  • ENSP00000473929
  • ENST00000604404
  • ENSP00000474438
  • ENST00000604621
  • ENSP00000474526
  • ENST00000605552
  • ENSP00000474855
  • ENST00000605677
  • ENSP00000474622

Symbol
  • MAT8
  • PLML
  • MAT8
  • PLML
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.85
transcription factor perturbation
0.8
virus perturbation
0.79
molecular function
0.76
phenotype
0.59


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.59   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.59   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (31)
ATP1B1
Tclin
Family:  Transporter
Novelty:  0.025056
Score:  0.924
Data Source:  STRINGDB
ATP1B2
Tclin
Family:  Transporter
Novelty:  0.02641193
Score:  0.923
Data Source:  STRINGDB
ATP1B3
Tclin
Family:  Transporter
Novelty:  0.06773518
Score:  0.92
Data Source:  STRINGDB
ATP1A1
Tclin
Family:  Transporter
Novelty:  0.01078788
Score:  0.915
Data Source:  STRINGDB
ATP1A2
Tclin
Family:  Transporter
Novelty:  0.00606202
Score:  0.914
Data Source:  STRINGDB
ATP1A3
Tclin
Family:  Transporter
Novelty:  0.00485594
Score:  0.912
Data Source:  STRINGDB
ATP1A4
Tclin
Family:  Transporter
Novelty:  0.01011201
Score:  0.904
Data Source:  STRINGDB
FXYD5
Tbio
Family:  IC
Novelty:  0.01598365
Score:  0.728
Data Source:  STRINGDB
FXYD7
Tbio
Family:  IC
Novelty:  0.08820333
Score:  0.705
Data Source:  STRINGDB
FXYD2
Tclin
Family:  Enzyme
Novelty:  0.0196518
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Ion channel transport
Reactome
Ion homeostasis
Reactome
Ion transport by P-type ATPases
Reactome
Muscle contraction
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Ion channel transport
Ion homeostasis
Ion transport by P-type ATPases
Muscle contraction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
3
8
10
99.4
calcium measurement
1
5
5
97.6
blood protein measurement
2
4
4
96.9
sex hormone-binding globulin measurement
6
2
6
94.7
mean platelet volume
3
3
3
93.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum albumin measurement
10
99.4
calcium measurement
5
97.6
blood protein measurement
4
96.9
sex hormone-binding globulin measurement
6
94.7
mean platelet volume
3
93.3
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 3
VGNC:11112
744576
Macaque
FXYD domain containing ion transport regulator 3
707346
Mouse
MGI:107497
17178
Rat
RGD:620825
116831
Dog
FXYD domain containing ion transport regulator 3
VGNC:41021
612671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FXYD domain containing ion transport regulator 3
Macaque
FXYD domain containing ion transport regulator 3
Mouse
Rat
Dog
FXYD domain containing ion transport regulator 3
Publication Statistics
PubMed Score 81.59
PubMed score by year
PubTator Score 35.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title